Perioperative Rehabilitation in Operable Lung Cancer Patients (PROLUCA): A Feasibility Study

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Dokumenter

Maja S Sommer, Karen Trier, Jette Vibe-Petersen, Malene Missel, Merete Christensen, Klaus R. Larsen, Seppo W. Langer, Carsten Hendriksen, Paul Frost Clementsen, Jesper H. Pedersen, Henning Langberg

Introduction: Surgical resection in patients with non-small cell lung cancer (NSCLC) may be associated with significant morbidity, functional limitations, and decreased quality of life.

Objectives: The safety and feasibility of a preoperative and early postoperative rehabilitation program in patients operated for NSCLC was determined in a nonhospital setting, with focus on high-intensity interval exercise.

Methods: Forty patients with biopsy-proven NSCLC stages I to IIIa referred for surgical resection at the Department of Cardiothoracic Surgery RT, Rigshospitalet, University of Copenhagen, were randomly assigned to 1 of 4 groups (3 intervention groups and 1 control group). The preoperative intervention consisted of a home-based exercise program, while the postoperative exercise program comprised a supervised group exercise program involving resistance and high-intensity interval cardiorespiratory exercise 2 hours weekly for 12 weeks combined with individual counseling. The study endpoints were inclusion rate, adherence, and number of adverse events.

Results: Forty patients (of 124 screened; 32%) were included and randomized into the 4 groups. The postoperative exercise was completed by 73% of the patients randomized to this intervention. No adverse events were observed, indicating that the early postoperative exercise program is safe. The preoperative home-based exercise program was not feasible due to interfering diagnostic procedures and fast-track surgery that left only 1 to 2 weeks between diagnosis and surgery.

Conclusion: The early postoperative exercise program for patients with NSCLC was safe and feasible, but in a fast-track set up, a preoperative home-based exercise program was not feasible for this population.

OriginalsprogEngelsk
TidsskriftIntegrative Cancer Therapies
Vol/bind15
Udgave nummer4
Sider (fra-til)455-466
Antal sider12
ISSN1534-7354
DOI
StatusUdgivet - 2016

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