Enantioselective Total Synthesis of (+)-Dihydro-β-erythroidine

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Sebastian Clementson, Mikkel Jessing, Henrik Pedersen, Paulo Vital, Jesper L Kristensen

Erythrina alkaloids represent a rich source of complex polycyclic, bioactive natural products. In addition to their sedative and hypotensive effect, their curare-like activity and structural framework have made them attractive targets for synthetic and medicinal chemists. (+)-Dihydro-β-erythroidine (DHβE), the most potent nicotine acetylcholine receptor antagonist (nAChR) of the Erythrina family, is synthesized for the first time in 13 steps from commercially available material.

OriginalsprogEngelsk
TidsskriftJournal of the American Chemical Society
Vol/bind141
Udgave nummer22
Sider (fra-til)8783-8786
ISSN0002-7863
DOI
StatusUdgivet - maj 2019

ID: 218709893