Sine Larsen

Sine Larsen

Professor Emerita


  1. 2018
  2. Published

    A comparative structural analysis of the surface properties of asco-laccases. / Ernst, Heidi A.; Jørgensen, Lise J.; Bukh, Christian; Piontek, Klaus; Plattner, Dietmar A.; Østergaard, Lars H.; Larsen, Sine; Bjerrum, Morten J.

    In: PLoS ONE, Vol. 13, No. 11, e0206589, 2018, p. 1-27.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    A new MR-SAD algorithm for the automatic building of protein models from low-resolution X-ray data and a poor starting model. / Skubak, Pavol; Arac, Demet; Bowler, Matthew W.; Correia, Ana R.; Hoelz, Andre; Larsen, Sine; Leonard, Gordon A.; McCarthy, Andrew A.; McSweeney, Sean; Mueller-Dieckmann, Christoph; Otten, Harm; Salzman, Gabriel; Pannu, Navraj S.

    In: I U Cr J, Vol. 5, No. Part 2, 2018, p. 166-171.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. 2017
  5. Published

    The nature of ancient Egyptian copper-containing carbon inks is revealed by synchrotron radiation based X-ray microscopy. / Christiansen, Thomas; Cotte, Marine; Loredo-Portales, René; Lindelof, Poul Erik; Mortensen, Kell; Ryholt, Kim; Larsen, Sine.

    In: Scientific Reports, 10.11.2017.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. 2015
  7. Published

    Crystallography is more than crystal structures. / Larsen, Sine.

    In: IUCrJ, Vol. 2, 2015, p. 475-476.

    Research output: Contribution to journalEditorialResearchpeer-review

  8. Published

    The function of the milk-clotting enzymes bovine and camel chymosin studied by a fluorescence resonance energy transfer assay. / Jensen, Jesper Langholm; Jacobsen, Jonas; Moss, Marcia L.; Rasmussen, Fred; Qvist, Karsten Bruun; Larsen, Sine; van den Brink, Johannes M.

    In: Journal of Dairy Science, Vol. 98, No. 5, 2015, p. 2853-2860.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. 2014
  10. Published

    A new insight into the zinc-dependent DNA-cleavage by the colicin E7 nuclease : a crystallographic and computational study. / Czene, Anikó; Tóth, Eszter; Németh, Eszter; Otten, Harm; Poulsen, Jens-Christian Navarro; Christensen, Hans Erik Mølager; Rulíšek, Lubomír; Nagata, Kyosuke; Larsen, Sine; Gyurcsik, Béla.

    In: Metallomics, Vol. 6, No. 11, 2014, p. 2090-2099.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    Crystallography and large research infrastructures, a perfect marriage. / Larsen, Sine.

    In: IUCrJ, Vol. 1, No. Part 5, 2014, p. 261-262.

    Research output: Contribution to journalEditorialResearchpeer-review

  12. Published

    Design of thermostable rhamnogalacturonan lyase mutants from Bacillus licheniformis by combination of targeted single point mutations. / da Silva, Ines Isabel Cardoso Rodrigues; Jers, Carsten; Otten, Harm; Nyffenegger, Christian; Larsen, Dorte Møller; Derkx, Patrick M.F.; Meyer, Anne S.; Mikkelsen, Jørn Dalgaard; Larsen, Sine.

    In: Applied Microbiology and Biotechnology, Vol. 98, No. 10, 2014, p. 4521-4531.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    Polysaccharide lyase family 4. / Lo Leggio, Leila; Larsen, Sine.

    Cazypedia. 2014.

    Research output: Chapter in Book/Report/Conference proceedingEncyclopedia chapterResearch

  14. 2013
  15. Published

    Molecular architecture of a complex between an adhesion protein from the malaria parasite and intracellular adhesion molecule 1. / Brown, Alan; Turner, Louise; Christoffersen, Stig; Andrews, Katrina A; Szestak, Tadge; Zhao, Yuguang; Larsen, Sine; Craig, Alister G; Higgins, Matthew K.

    In: Journal of Biological Chemistry, Vol. 288, No. 8, 22.02.2013, p. 5992-6003.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    Camel and bovine chymosin : the relationship between their structures and cheese-making properties. / Jensen, Jesper Langholm; Mølgaard, Anne; Poulsen, Jens-Christian Navarro; Harboe, Marianne Kirsten; Simonsen, Jens Bæk; Lorentzen, Andrea Maria; Hjernø, Karin; van den Brink, Johannes M.; Qvist, Karsten Bruun; Larsen, Sine.

    In: Acta Crystallographica. Section D: Biological Crystallography, Vol. D69, 2013, p. 901-913.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    Crystallization and preliminary crystallographic analysis of an Escherichia coli-selected mutant of the nuclease domain of the metallonuclease colicin E7. / Czene, Anikó; Toth, Eszter; Gyurcsik, Béla; Otten, Harm; Poulsen, Jens-Christian Navarro; Lo Leggio, Leila; Larsen, Sine; Christensen, Hans E.M.; Nagata, Kyosuke.

    In: Acta Crystallographica. Section F: Structural Biology and Crystallization Communications Online, Vol. 69, 2013, p. 551-554.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    The binding of zinc ions to Emericella nidulans endo-β-1,4-galactanase is essential for crystal formation. / Otten, Harm; Michalak, Malwina; Mikkelsen, Jørn Dalgaard; Larsen, Sine.

    In: Acta Crystallographica. Section F: Structural Biology and Crystallization Communications Online, Vol. F69, No. 8, 2013, p. 850-854.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. 2012
  20. Published

    Structural and functional insight into how the Plasmodium falciparum VAR2CSA protein mediates binding to chondroitin sulfate A in placental malaria. / Clausen, Thomas M; Christoffersen, Stig; Dahlbäck, Madeleine; Langkilde, Annette Eva; Jensen, Kamilla E; Resende, Mafalda; Agerbæk, Mette Ø; Andersen, Daniel; Berisha, Besim; Ditlev, Sisse B; Pinto, Vera V; Nielsen, Morten A; Theander, Thor G; Larsen, Sine; Salanti, Ali.

    In: Journal of Biological Chemistry, Vol. 287, No. 28, 2012, p. 23332-45.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. 2011
  22. Published

    Understanding Thermodynamic Properties at the Molecular Level: Multiple Temperature Charge Density Study of Ribitol and Xylitol. / Madsen, Anders Østergaard; Mattson, Rikke; Larsen, Sine.

    In: Journal of Physical Chemistry Part A: Molecules, Spectroscopy, Kinetics, Environment and General Theory, Vol. 115, 2011, p. 7794–7804.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. 2010
  24. Published

    Citations in supplementary material. / Weiss, M. S.; Einspahr, H.; Baker, E. N.; Dauter, Z.; Kaysser-Pyzalla, A. R.; Kostorz, G.; Larsen, Sine.

    In: Journal of Applied Crystallography, Vol. 43, 2010, p. 1285-1286.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Stimulation of lignocellulosic biomass hydrolysis by proteins of glycoside hydrolase family 61: Structure and function of a large, enigmatic family. / Harris, Paul V; Welner, Ditte Hededam; McFarland, KC; Re, E; Poulsen, Jens-Christian Navarro; Brown, K; Salbo, Rune; Ding, H; Vlasenko, E; Marino, Sandy; Xu, F; Cherry, Joel; Larsen, Sine; Lo Leggio, Leila.

    In: Biochemistry, Vol. 49, 2010, p. 3305-3316.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published

    Structural and biochemical studies elucidate the mechanism of rhamnogalacturonan lyase from Aspergillus aculeatus. / Jensen, Malene Hillerup; Otten, Harm; Christensen, Ulla; Borchert, Torben V.; Christensen, Lars L. H.; Larsen, Sine; Lo Leggio, Leila.

    In: Journal of Molecular Biology, Vol. 404, 2010, p. 100-111.

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. 2009
  28. Published

    Concerted bifunctionality of the dCTP deaminase-dUTPase from Methanocaldococcus jannaschii: a structural and pre-steady state kinetic analysis. / Siggaard, Julie H B; Johansson, Eva; Vognsen, Tina Reinholdt; Helt, Signe Smedegaard; Harris, Pernille; Larsen, Sine; Willemoës, Martin.

    In: Archives of Biochemistry and Biophysics, Vol. 490, No. 1, 2009, p. 42-9.

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Published

    Investigating the binding of beta-1,4-galactan to Bacillus licheniformis beta-1,4-galactanase by crystallography and computational modeling. / Le Nours, Jerome; De Maria, Leonardo; Welner, Ditte Hededam; Jørgensen, Christel T; Borchert, Torben V.; Christensen, Lars LH; Larsen, Sine; Lo Leggio, Leila.

    In: Proteins - Structure Function and Bioinformatics, Vol. 75, 2009, p. 977-989.

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. 2008
  31. Published

    Estimated H-atom anisotropic displacement parameters: a comparison between different methods and with neutron diffraction results. / Munshi, Parthapratim; Madsen, Anders Ø; Spackman, Mark A; Larsen, Sine; Destro, Riccardo.

    In: Acta Crystallographica. Section A: Foundations of Crystallography, Vol. A64, 2008, p. 465-75.

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. Published

    Identification of Quaternary Structure and functional domains of the CI repressor from Bacteriophage TP901-1. / Pedersen, Margit; Lo Leggio, Leila; Grossmann, J. Günter; Larsen, Sine Ydun; Hammer, Karin.

    In: Journal of Molecular Biology, Vol. 373, 2008, p. 983-996.

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published

    Mechanism of dTTP inhibition of the bifunctional dCTP deaminase:dUTPase encoded by Mycobacterium tuberculosis. / Helt, Signe Smedegaard; Thymark, Majbritt; Harris, Pernille; Aagaard, Claus; Dietrich, Jes; Larsen, Sine; Willemoes, Martin.

    In: Journal of Molecular Biology, Vol. 376, No. 2, 2008, p. 554-69.

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published

    Short strong hydrogen bonds in proteins: a case study of rhamnogalacturonan acetylesterase. / Langkilde, Annette Eva; Kristensen, Søren Martin; Lo Leggio, Leila; Mølgaard, Anne; Jensen, Jan Halborg; Houk, Andrew R.; Poulsen, Jens-Christian Navarro; Larsen, Sine Ydun; Kauppinen, S.

    In: Acta Crystallographica. Section D: Biological Crystallography, Vol. 64, 2008, p. 851-863.

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. Published

    Structure and function of enzymes in biomass degradation. / Welner, Ditte Hededam; Jensen, Malene Hillerup; McFarland, Keith Charles; Poulsen, Jens-Christian Navarro; Otten, Harm; Salbo, Rune; Christensen, Ulla; Harris, Pernille; Larsen, Sine; Borchert, Torben; Christensen, Lars L. H.; Friis, Esben Peter; Lo Leggio, Leila.

    Biotechnology of lignocellulose degradation and Biomass Utilization - Mie Bioforum 2008. 2008. p. 349-355.

    Research output: Chapter in Book/Report/Conference proceedingArticle in proceedingsResearch

  36. 2007
  37. Published

    Insight into Solid-State Entropy from Diffraction Data. / Madsen, Anders Østergaard; Larsen, Sine.

    In: Angewandte Chemie - International Edition, Vol. 46, No. 45, 2007, p. 8609-8613.

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. Published

    Interaction of benzoate pyrimidine analogues with class 1A dihydroorotate dehydrogenase from Lactococcus lactis. / Wolfe, Abigail E; Thymark, Majbritt; Gattis, Samuel G; Fagan, Rebecca L; Hu, Yu-chen; Johansson, Eva; Arent, Susan; Larsen, Sine; Palfey, Bruce A.

    In: Biochemistry, Vol. 46, No. 19, 2007, p. 5741-53.

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. Published

    Mutational analysis of the nucleotide binding site of Escherichia coli dCTP deaminase. / Thymark, Majbritt; Johansson, Eva; Larsen, Sine; Willemoës, Martin.

    In: Archives of Biochemistry and Biophysics, Vol. 470, No. 1, 2007, p. 20-6.

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Published

    Regulation of dCTP deaminase from Escherichia coli by nonallosteric dTTP binding to an inactive form of the enzyme. / Johansson, Eva; Thymark, Majbritt; Bynck, Julie H; Fanø, Mathias; Larsen, Sine; Willemoës, Martin.

    In: FEBS Journal, Vol. 274, No. 16, 2007, p. 4188-4198.

    Research output: Contribution to journalJournal articleResearchpeer-review

  41. Published

    The crystal structure of human dipeptidyl peptidase I (cathepsin C) in complex with the inhibitor Gly-Phe-CHN2. / Mølgaard, Anne; Arnau, Jose; Lauritzen, Conni; Larsen, Sine; Petersen, Gitte; Pedersen, John.

    In: Biochemical Journal, Vol. 401, No. 3, 2007, p. 645-50.

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. 2006
  43. Automation of sample mounting for macromolecular crystallography. / Cipriani, F.; Felisaz, F.; Launer, L.; Aksoy, J.-S.; Caserotto, H.; Cusack, S.; Dallery, M.; di-Chiaro, F.; Guijarr, M.; Huet, J.; Larsen, Sine; Lentini, M.; McCarthy, Janice; McSweeeney, S.; Ravelli, R.; Renier, M.; Taffut, C.; Thompson, A..; Leonard, G. A.; Walsh, M.. A.

    In: Acta Crystallographica. Section D: Biological Crystallography, Vol. 62, No. 10, 2006, p. 1251-1259.

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. High-throughput sample handling and data collection at synchrotrons : embedding the ESRF in the high-throughput gene-to-structure pipeline. / Beteva, A.; Cipriani, F.; Cusack, S.; Delageniere, S.; Gabadinho, J.; Gordon, E. J.; Guijarro, M.; Hall, D. R.; Larsen, Sine; Launer, L.; Lavault, C. B.; Leonard, G. A.; Mairs, T.; McCarthy, A.; McCarthy, Janice; Meyer, J.; Mitchell, E.; Monaco, S.; Nurizzo, D.; Pernot, P.; Pieritz, R.; Ravelli, G. .B.; Rey, V.; Shepard, W.; Spruce, D.; Stuart, D. I.; Svensson, O.; Theveneau, P.; Thibault, X.; Turkenburg, J.; Walsh, M.; McSweeney, S. M.

    In: Acta Crystallographica. Section D: Biological Crystallography, Vol. 62, No. 10, 2006, p. 1162-1169.

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. Published

    Structure of the Sulfolobus solfataricus alpha-glucosidase: Implications for domain conservation and substrate recognition in GH31. / Ernst, Heidi Asschenfeldt; Lo Leggio, Leila; Willemoes, M.; Leonard, G. A.; Blum, P.; Larsen, Sine.

    In: Journal of Molecular Biology, Vol. 358, No. 4, 2006, p. 1106-24.

    Research output: Contribution to journalJournal articleResearchpeer-review

  46. Published

    The extraordinary specificity of xanthine phosphoribosyltransferase from Bacillus subtilis elucidated by reaction kinetics, ligand binding, and crystallography. / Arent, Susan; Kadziola, Anders; Larsen, Sine; Neuhard, Jan; Jensen, Kaj Frank.

    In: Biochemistry, Vol. 45, No. 21, 2006, p. 6615-6627.

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. 2005
  48. Published

    Tetra-tert-butyl-di-μ-hydroxo digallium(III) and 1,12-diaza-3,4:9,10- dibenzo-5,8-dioxo-cyclo-pentadecane. Structure and isomers of the coordination compound. / Sun, Hongsui; Thulstrup, Peter W.; Larsen, Sine; Larsen, Erik.

    In: International Journal of Molecular Sciences, Vol. 6, No. 11, 01.11.2005, p. 276-290.

    Research output: Contribution to journalJournal articleResearchpeer-review

  49. Published

    2-(1-Naphthyl)propionic acid. / Riis, Erik Pedersen; Larsen, Sine.

    In: Acta Crystallographica. Section E: Structure Reports Online, No. E61, 2005, p. o1396-o1397.

    Research output: Contribution to journalJournal articleResearchpeer-review

  50. Published

    Allosteric properties of the GTP activated and CTP inhibited uracil phosphoribosyltransferase from the thermoacidophilic archeon Sulfolobus solfataricus. / Jensen, K. F.; Arent, Susan; Larsen, Sine; Schack, L.

    In: FEBS Journal, No. 272, 2005, p. 1440-1453.

    Research output: Contribution to journalJournal articleResearchpeer-review

  51. Published

    Allosteric regulation and communication between subunits in uracil phosphoribosyltransferase from Sulfolobus solfataricus. / Arent, Susan; Harris, Pernille; Jensen, Kaj Frank; Larsen, Sine.

    In: Biochemistry, Vol. 44, No. 3, 2005, p. 883-892.

    Research output: Contribution to journalJournal articleResearchpeer-review

  52. Published

    Allosteric regulation of the GTP activated and CTP inhibited uracil phosphoribosyltransferase from the thermophilic archaeon Sulfolobus solfataricus. / Jensen, Kaj Frank; Arent, Susan; Larsen, Sine; Schack, Lise.

    In: FEBS Journal, Vol. 272, No. 6, 2005, p. 1440-1453.

    Research output: Contribution to journalJournal articleResearchpeer-review

  53. Published

    Characterization of different crystal forms of the a-glucosidase MalA from Sulfolobus solfataricus. / Ernst, Heidi Asschenfeldt; Willemoës, Martin; Lo Leggio, Leila; Leonard, Gordon; Blum, Paul; Larsen, Sine.

    In: Acta Crystallographica Section F, Vol. 61, 2005, p. 1039-1042.

    Research output: Contribution to journalJournal articleResearchpeer-review

  54. Published

    Characterization of different crystal forms of the alpha-glucosidase MalA from Sulfolobus solfataricus. / Ernst, Heidi Asschenfeldt; Willemoës, Martin; Lo Leggio, Leila; Leonard, Gordon; Blum, Paul; Larsen, Sine.

    In: Acta Crystallographica. Section F : Structural Biology and Crystallization Communications, Vol. 61, No. Pt 12, 2005, p. 1039-42.

    Research output: Contribution to journalJournal articleResearchpeer-review

  55. Published

    Facile cobalt(III) template synthesis of novel branched hexadentate polyamine monocarboxylates. / Barfod, Rasmus; Eriksen, Jette; Golding, Bernard T.; Hammershøi, Anders; Jacobsen, Thomas Amos; Langkilde, Annette Eva; Larsen, Sine; Mønsted, O.; Sargeson, Alan M.; Sørensen, Henning Osholm.

    In: Dalton Transactions (Print Edition), No. 3, 2005, p. 491-500.

    Research output: Contribution to journalJournal articleResearchpeer-review

  56. Published

    Identification and analysis of 21 novel disease-causing amino acid substitutions in the conserved part of ATP7A. / Møller, Lisbeth Birk; Bukrinsky, Jens Thostrup; Mølgaard, Anne; Paulsen, Marianne; Lund, Connie; Tümer, Zeynep; Larsen, Sine; Horn, Nina.

    In: Human Mutation, Vol. 26, 2005, p. 84-93.

    Research output: Contribution to journalJournal articleResearchpeer-review

  57. Published

    Novel class III phosphoribosyl diphosphate synthase: structure and properties of the tetrameric, phosphate-activated, non-allosterically inhibited enzyme from Methanocaldococcus jannaschii. / Kadziola, Anders; Jepsen, Clemens H; Johansson, Eva; McGuire, Jim; Larsen, Sine; Hove-Jensen, Bjarne.

    In: Journal of Molecular Biology, Vol. 354, No. 4, 2005, p. 815-28.

    Research output: Contribution to journalJournal articleResearchpeer-review

  58. Published

    Probing the structure of glucan lyases by sequence analysis, circular dichroism and proteolysis. / Ernst, Heidi Asschenfeldt; Lo Leggio, Leila; Yu, Shukun; Finnie, Christine; Svensson, Birte; Larsen, Sine.

    In: Biologia, Vol. 60, No. Suppl. 16, 2005, p. 149-159.

    Research output: Contribution to journalJournal articleResearchpeer-review

  59. Published

    Structures of dCTP deaminase from Escherichia coli with bound substrate and product. / Johansson, Eva Helena; Fanø, Mathias; Bynck, Julie H.; Neuhard, J.; Larsen, Sine; Sigurdskjold, B.; Christensen, Ulla; Willemoës, M.

    In: The Journal of Biological Chemistry, No. 280, 2005, p. 3051-3059.

    Research output: Contribution to journalJournal articleResearchpeer-review

  60. 2004
  61. Published

    Bis(quininium) (R,R)-tartrate monohydrate. / Ryttersgaard, Carsten; Larsen, Sine.

    In: Acta Crystallographica. Section E: Structure Reports Online, No. 60, 2004, p. 04-05.

    Research output: Contribution to journalJournal articleResearchpeer-review

  62. Published

    Charge Density Study of Naphthalene Based on X-ray Diffraction Data at Four Different Temperatures and Theoretical Calculations. / Oddershede, Jette; Larsen, Sine.

    In: Journal of Physical Chemistry A, No. 108, 2004, p. 1057-1063.

    Research output: Contribution to journalJournal articleResearchpeer-review

  63. Published

    Crystal packing in two pH-dependent crystal forms of rhamnogalacturonan acetylesterase. / Mølgaard, Anne; Larsen, Sine.

    In: Acta Crystallographica. Section D: Biological Crystallography, Vol. D60, 2004, p. 472-478.

    Research output: Contribution to journalJournal articleResearchpeer-review

  64. Published

    High-throughput physical characterization of protein solutions using microfluides. / Sommer, Morten Otto Alexander; Poulsen, Jens-Christian Navarro; Larsen, Sine.

    In: Acta Crystallographica, No. A60, 2004, p. 206.

    Research output: Contribution to journalJournal articleResearchpeer-review

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