The role of tumor necrosis factor-α and TNF-α receptors in cerebral arteries following cerebral ischemia in rat

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Aida Maddahi, Lars S Kruse, Qing-Wen Chen, Lars Edvinsson

Tumour necrosis factor-a (TNF-a) is a pleiotropic pro-inflammatory cytokine, which is rapidly upregulated in the brain after injury. TNF-a acts by binding to its receptors, TNF-R1 (p55) and TNF-R2 (p75), on the cell surface. The aim of this study was first to investigate if there is altered expression of TNF-a and TNF-a receptors in cerebral artery walls following global or focal ischemia, and after organ culture. Secondly, we asked if the expression was regulated via activation of the MEK-ERK1/2 pathway.
OriginalsprogEngelsk
TidsskriftJournal of Neuroinflammation
Vol/bind8
Sider (fra-til)107
ISSN1742-2094
DOI
StatusUdgivet - 2011

ID: 40150090