Bovine colostrum to children with short bowel syndrome: A randomized, double-blind, crossover pilot study

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Lise Aunsholt, Palle Bekker Jeppesen, Pernille Lund, Per Torp Sangild, Inge Bøtker Rasmussen Ifaoui, Niels Qvist, Steffen Husby

Background: Management of short bowel syndrome (SBS) aims to achieve intestinal autonomy to prevent fluid, electrolyte, and nutrient deficiencies and maintain adequate development. Remnant intestinal adaptation is required to obtain autonomy. In the newborn pig, colostrum has been shown to support intestinal development and hence adaptive processes. Aim: The efficacy of bovine colostrum to improve intestinal function in children with SBS was evaluated by metabolic balance studies. Materials and Methods: Nine children with SBS were included in a randomized, double-blind, crossover study. Twenty percent of enteral fluid intake was replaced with bovine colostrum or a mixed milk diet for 4 weeks, separated by a 4-week washout period. Intestinal absorption of energy and wet weight was used to assess intestinal function and the efficacy of colostrum. Results: Colostrum did not improve energy or wet weight absorption compared with the mixed milk diet (P = 1.00 and P = .93, respectively). Growth as measured by weight and knemometry did not differ between diets (P = .93 and P = .28). In these patients,
OriginalsprogEngelsk
TidsskriftJournal of Parenteral and Enteral Nutrition
Vol/bind38
Udgave nummer1
Sider (fra-til)99-106
Antal sider8
ISSN0148-6071
DOI
StatusUdgivet - 2014

Bibliografisk note

CURIS 2014 NEXS 013

ID: 44162852