Neuroendocrine control of Drosophila larval light preference

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Naoki Yamanaka, Nuria M. Romero, Francisco A. Martin, Kim Furbo Rewitz, Mu Sun, Michael B. O´Connor, Pierre Léopold

Animal development is coupled with innate behaviors that maximize chances of survival. Here, we show that the prothoracicotropic hormone (PTTH), a neuropeptide that controls the developmental transition from juvenile stage to sexual maturation, also regulates light avoidance in Drosophila melanogaster larvae. PTTH, through its receptor Torso, acts on two light sensors???the Bolwig???s organ and the peripheral class IV dendritic arborization neurons???to regulate light avoidance. We found that PTTH concomitantly promotes steroidogenesis and light avoidance at the end of larval stage, driving animals toward a darker environment to initiate the immobile maturation phase. Thus, PTTH controls the decisions of when and where animals undergo metamorphosis, optimizing conditions for adult development.
OriginalsprogEngelsk
TidsskriftScience
Vol/bind341
Udgave nummer6150
Sider (fra-til)1113-1116
Antal sider4
ISSN0036-8075
DOI
StatusUdgivet - 2013

ID: 65571079