Electromembrane extraction as a rapid and selective miniaturized sample preparation technique for biological fluids

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Astrid Gjelstad, Stig Pedersen-Bjergaard, Knut Fredrik Seip

This special report discusses the sample preparation method electromembrane extraction, which was introduced in 2006 as a rapid and selective miniaturized extraction method. The extraction principle is based on isolation of charged analytes extracted from an aqueous sample, across a thin film of organic solvent, and into an aqueous receiver solution. The extraction is promoted by application of an electrical field, causing electrokinetic migration of the charged analytes. The method has shown to perform excellent clean-up and selectivity from complicated aqueous matrices like biological fluids. Technical aspects of electromembrane extraction, important extraction parameters as well as a handful of examples of applications from different biological samples and bioanalytical areas are discussed in the paper.
OriginalsprogEngelsk
TidsskriftBioanalysis
Vol/bind7
Udgave nummer17
Sider (fra-til)2203-2209
Antal sider7
ISSN1757-6180
DOI
StatusUdgivet - 2015

ID: 154176806