Insulin-like growth factor I and anthropometric parameters in a Danish population

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N Friedrich, Torben Jørgensen, A Juul, C Spielhagen, M Nauck, H Wallaschofski, A Linneberg

During the last decade several studies indicated that low insulin-like growth factor (IGF) I levels are related to higher risk of cardiovascular disease and mortality. Obesity represents one further main cardiovascular risk factor which might also be related to IGF-I. The objective of the present study was to analyse the associations between anthropometric measures and IGF-I levels in a population-based sample. From the Danish cross-sectional Health2006 study 3,328 subjects (1,835 women; 1,493 men) aged 19-72 years were included in the analyses. Serum IGF-I levels were determined by an immunoassay. Body height, weight as well as waist and hip circumferences were measured. Body-mass-index, waist-to-hip ratio and waist-to-height ratio were calculated. Circulating IGF-I levels were inversely associated with all anthropometric markers as evaluated by linear regression adjusting for age, alcohol consumption, smoking and physical activity. Our large cross-sectional study suggests that IGF-I may serve as the link between obesity and mortality although any causal relation cannot be inferred and longitudinal analyses are needed to clarify the causal relation.
OriginalsprogEngelsk
TidsskriftExperimental and Clinical Endocrinology and Diabetes
Vol/bind120
Udgave nummer3
Sider (fra-til)171-4
Antal sider4
ISSN0947-7349
DOI
StatusUdgivet - 2012

ID: 40167097