UV imaging for in vitro dissolution and release studies: Initial experiences

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Jesper Østergaard, James Lenke, Sabrine Smedegaard Jensen, Yu Sun, Fengbin Ye

UV imaging has recently been introduced as a method in drug dissolution and release testing. Spatially and temporally resolved mapping of drug oncentrations in a 7 × 9 mm imaging area provides new opportunities for visualization and study of drug dissolution and release. This review describes the current strumentation and principles of analysis. Pharmaceutical applications of UV imaging are presented, including etermination of dissolution rates for drug substances, cocrystals, and nanocrystals and monitoring of solid form changes and single crystal dissolution as well as drug release and transport in hydrogels with relevance for characterization of parenteral depots. UV imaging may be of particular use when the amounts of material are sparse and detailed insights into dissolution and release processes are required, that is in solid form screening, preformulation, and early drug development.
OriginalsprogEngelsk
TidsskriftDissolution Technologies
Vol/bind21
Udgave nummer4
Sider (fra-til)27-38
Antal sider12
ISSN1521-298X
DOI
StatusUdgivet - 2014

ID: 137599207