Synthesis of new isoxazoline-based acidic amino acids and investigation of their affinity and selectivity profile at ionotropic glutamate receptors

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Andrea Pinto, Paola Conti, Giovanni Grazioso, Lucia Tamborini, Ulf Madsen, Birgitte Nielsen, Carlo De Micheli

The synthesis of four new isoxazoline-based amino acids being analogues of previously described glutamate receptor ligands is reported and their affinity for ionotropic glutamate receptors is analyzed in comparison with that of selected model compounds. Molecular modelling investigations have been carried out to rationalize the interaction with the NMDA receptors.
OriginalsprogEngelsk
TidsskriftEuropean Journal of Medicinal Chemistry
Vol/bind46
Udgave nummer2
Sider (fra-til)787-793
ISSN0223-5234
DOI
StatusUdgivet - 1 feb. 2011

Bibliografisk note

Keywords: glutamic acid, ionotropic Glu receptors, isoxazoline, 1,3-dipolar cycloaddition

ID: 33687646