Phenotypic and functional plasticity of cells of innate immunity: macrophages, mast cells and neutrophils

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Phenotypic and functional plasticity of cells of innate immunity: macrophages, mast cells and neutrophils. / Galli, Stephen J; Borregaard, Niels; Wynn, Thomas A.

I: Nature Immunology, Bind 12, Nr. 11, 2011, s. 1035-44.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Galli, SJ, Borregaard, N & Wynn, TA 2011, 'Phenotypic and functional plasticity of cells of innate immunity: macrophages, mast cells and neutrophils', Nature Immunology, bind 12, nr. 11, s. 1035-44. https://doi.org/10.1038/ni.2109

APA

Galli, S. J., Borregaard, N., & Wynn, T. A. (2011). Phenotypic and functional plasticity of cells of innate immunity: macrophages, mast cells and neutrophils. Nature Immunology, 12(11), 1035-44. https://doi.org/10.1038/ni.2109

Vancouver

Galli SJ, Borregaard N, Wynn TA. Phenotypic and functional plasticity of cells of innate immunity: macrophages, mast cells and neutrophils. Nature Immunology. 2011;12(11):1035-44. https://doi.org/10.1038/ni.2109

Author

Galli, Stephen J ; Borregaard, Niels ; Wynn, Thomas A. / Phenotypic and functional plasticity of cells of innate immunity: macrophages, mast cells and neutrophils. I: Nature Immunology. 2011 ; Bind 12, Nr. 11. s. 1035-44.

Bibtex

@article{0cf9e7174f56445db5abf05597d2491f,
title = "Phenotypic and functional plasticity of cells of innate immunity: macrophages, mast cells and neutrophils",
abstract = "Hematopoietic cells, including lymphoid and myeloid cells, can develop into phenotypically distinct 'subpopulations' with different functions. However, evidence indicates that some of these subpopulations can manifest substantial plasticity (that is, undergo changes in their phenotype and function). Here we focus on the occurrence of phenotypically distinct subpopulations in three lineages of myeloid cells with important roles in innate and acquired immunity: macrophages, mast cells and neutrophils. Cytokine signals, epigenetic modifications and other microenvironmental factors can substantially and, in some cases, rapidly and reversibly alter the phenotype of these cells and influence their function. This suggests that regulation of the phenotype and function of differentiated hematopoietic cells by microenvironmental factors, including those generated during immune responses, represents a common mechanism for modulating innate or adaptive immunity.",
author = "Galli, {Stephen J} and Niels Borregaard and Wynn, {Thomas A}",
year = "2011",
doi = "http://dx.doi.org/10.1038/ni.2109",
language = "English",
volume = "12",
pages = "1035--44",
journal = "Nature Immunology",
issn = "1529-2908",
publisher = "nature publishing group",
number = "11",

}

RIS

TY - JOUR

T1 - Phenotypic and functional plasticity of cells of innate immunity: macrophages, mast cells and neutrophils

AU - Galli, Stephen J

AU - Borregaard, Niels

AU - Wynn, Thomas A

PY - 2011

Y1 - 2011

N2 - Hematopoietic cells, including lymphoid and myeloid cells, can develop into phenotypically distinct 'subpopulations' with different functions. However, evidence indicates that some of these subpopulations can manifest substantial plasticity (that is, undergo changes in their phenotype and function). Here we focus on the occurrence of phenotypically distinct subpopulations in three lineages of myeloid cells with important roles in innate and acquired immunity: macrophages, mast cells and neutrophils. Cytokine signals, epigenetic modifications and other microenvironmental factors can substantially and, in some cases, rapidly and reversibly alter the phenotype of these cells and influence their function. This suggests that regulation of the phenotype and function of differentiated hematopoietic cells by microenvironmental factors, including those generated during immune responses, represents a common mechanism for modulating innate or adaptive immunity.

AB - Hematopoietic cells, including lymphoid and myeloid cells, can develop into phenotypically distinct 'subpopulations' with different functions. However, evidence indicates that some of these subpopulations can manifest substantial plasticity (that is, undergo changes in their phenotype and function). Here we focus on the occurrence of phenotypically distinct subpopulations in three lineages of myeloid cells with important roles in innate and acquired immunity: macrophages, mast cells and neutrophils. Cytokine signals, epigenetic modifications and other microenvironmental factors can substantially and, in some cases, rapidly and reversibly alter the phenotype of these cells and influence their function. This suggests that regulation of the phenotype and function of differentiated hematopoietic cells by microenvironmental factors, including those generated during immune responses, represents a common mechanism for modulating innate or adaptive immunity.

U2 - http://dx.doi.org/10.1038/ni.2109

DO - http://dx.doi.org/10.1038/ni.2109

M3 - Journal article

VL - 12

SP - 1035

EP - 1044

JO - Nature Immunology

T2 - Nature Immunology

JF - Nature Immunology

SN - 1529-2908

IS - 11

ER -

ID: 40146463