Partial agonists and subunit selectivity at NMDA receptors

Publikation: Bidrag til tidsskriftReviewForskningfagfællebedømt

Rune Risgaard, Kasper Bø Hansen, Rasmus Prætorius Clausen

Subunit-selective ligands for glutamate receptors remains an area of interest as glutamate is the major excitatory neurotransmitter in the brain and involved in a number of diseased states in the central nervous system (CNS). Few subtype-selective ligands are known, especially among the N-methyl-D-aspartic acid (NMDA) receptor class. Development of these ligands seems to be a difficult task because of the conserved region in the binding site of the NMDA receptor subunits. A few scaffolds have been developed showing potential to differentiate between the NMDA receptors.
OriginalsprogEngelsk
TidsskriftChemistry: A European Journal
Vol/bind16
Udgave nummer47
Sider (fra-til)13910-13918
ISSN0947-6539
DOI
StatusUdgivet - 17 dec. 2010

Bibliografisk note

Keywords: agonists, glutamate, ligand design, receptors, subunit selectivity

ID: 33701222