Partial agonists and subunit selectivity at NMDA receptors
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
Rune Risgaard, Kasper Bø Hansen, Rasmus Prætorius Clausen
Subunit-selective ligands for glutamate receptors remains an area of interest as glutamate is the major excitatory neurotransmitter in the brain and involved in a number of diseased states in the central nervous system (CNS). Few subtype-selective ligands are known, especially among the N-methyl-D-aspartic acid (NMDA) receptor class. Development of these ligands seems to be a difficult task because of the conserved region in the binding site of the NMDA receptor subunits. A few scaffolds have been developed showing potential to differentiate between the NMDA receptors.
|Tidsskrift||Chemistry: A European Journal|
|Status||Udgivet - 17 dec. 2010|
Keywords: agonists, glutamate, ligand design, receptors, subunit selectivity
- Det Farmaceutiske Fakultet