Neuritogenic and neuroprotective properties of peptide agonists of the fibroblast growth factor receptor

Publikation: Bidrag til tidsskriftReviewForskning

Shizhong Li, Elisabeth Marianne Bock, Vladimir Berezin

Fibroblast growth factor receptors (FGFRs) interact with their cognate ligands, FGFs, and with a number of cell adhesion molecules (CAMs), such as the neural cell adhesion molecule (NCAM), mediating a wide range of events during the development and maintenance of the nervous system. Determination of protein structure, in silico modeling and biological studies have recently resulted in the identification of FGFR binding peptides derived from various FGFs and NCAM mimicking the effects of these molecules with regard to their neuritogenic and neuroprotective properties. This review focuses on recently developed functional peptide agonists of FGFR with possible therapeutic potential.
OriginalsprogEngelsk
TidsskriftInternational Journal of Molecular Sciences (Online)
Vol/bind11
Udgave nummer6
Sider (fra-til)2291-2305
Antal sider15
ISSN1661-6596
DOI
StatusUdgivet - 26 maj 2010

ID: 33903782