Mono-ovulation in women with polycystic ovary syndrome: a clinical review on ovulation induction

Publikation: Bidrag til tidsskriftReviewForskningfagfællebedømt

Standard

Mono-ovulation in women with polycystic ovary syndrome : a clinical review on ovulation induction. / Birch Petersen, Kathrine; Pedersen, Nina Gros; Pedersen, Anette Tønnes; Lauritsen, Mette Petri; Freiesleben, Nina la Cour.

I: Reproductive BioMedicine Online, Bind 32, Nr. 6, 06.2016, s. 563-83.

Publikation: Bidrag til tidsskriftReviewForskningfagfællebedømt

Harvard

Birch Petersen, K, Pedersen, NG, Pedersen, AT, Lauritsen, MP & Freiesleben, NLC 2016, 'Mono-ovulation in women with polycystic ovary syndrome: a clinical review on ovulation induction', Reproductive BioMedicine Online, bind 32, nr. 6, s. 563-83. https://doi.org/10.1016/j.rbmo.2016.03.006

APA

Birch Petersen, K., Pedersen, N. G., Pedersen, A. T., Lauritsen, M. P., & Freiesleben, N. L. C. (2016). Mono-ovulation in women with polycystic ovary syndrome: a clinical review on ovulation induction. Reproductive BioMedicine Online, 32(6), 563-83. https://doi.org/10.1016/j.rbmo.2016.03.006

Vancouver

Birch Petersen K, Pedersen NG, Pedersen AT, Lauritsen MP, Freiesleben NLC. Mono-ovulation in women with polycystic ovary syndrome: a clinical review on ovulation induction. Reproductive BioMedicine Online. 2016 jun;32(6):563-83. https://doi.org/10.1016/j.rbmo.2016.03.006

Author

Birch Petersen, Kathrine ; Pedersen, Nina Gros ; Pedersen, Anette Tønnes ; Lauritsen, Mette Petri ; Freiesleben, Nina la Cour. / Mono-ovulation in women with polycystic ovary syndrome : a clinical review on ovulation induction. I: Reproductive BioMedicine Online. 2016 ; Bind 32, Nr. 6. s. 563-83.

Bibtex

@article{8252e098ebe0436493bc81cb67e3d850,
title = "Mono-ovulation in women with polycystic ovary syndrome: a clinical review on ovulation induction",
abstract = "Polycystic ovary syndrome (PCOS) affects 5-10{\%} of women of reproductive age and is the most common cause of anovulatory infertility. The treatment approaches to ovulation induction vary in efficacy, treatment duration and patient friendliness. The aim was to determine the most efficient, evidence-based method to achieve mono-ovulation in women diagnosed with PCOS. Publications in English providing information on treatment, efficacy and complication rates were included until September 2015. Systematic reviews, meta-analyses and randomized controlled trials were favoured over cohort and retrospective studies. Clomiphene citrate is recommended as primary treatment for PCOS-related infertility. It induces ovulation in three out of four patients, the risk of multiple pregnancies is modest and the treatment is simple and inexpensive. Gonadotrophins are highly efficient in a low-dose step-up regimen. Ovulation rates are improved by lifestyle interventions in overweight women. Metformin may improve the menstrual cycle within 1-3 months, but does not improve the live birth rate. Letrozole is effective for ovulation induction, but is an off-label drug in many countries. Ovulation induction in women with PCOS should be individualized with regard to weight, treatment efficacy and patient preferences with the aim of achieving mono-ovulation and subsequently the birth of a singleton baby.",
keywords = "Adult, Anovulation, Body Weight, Clomiphene, Female, Fertility Agents, Female, Gonadotropins, Humans, Infertility, Female, Life Style, Metformin, Nitriles, Overweight, Ovulation, Ovulation Induction, Patient Safety, Polycystic Ovary Syndrome, Randomized Controlled Trials as Topic, Reproductive Techniques, Assisted, Retrospective Studies, Triazoles, Journal Article, Review",
author = "{Birch Petersen}, Kathrine and Pedersen, {Nina Gros} and Pedersen, {Anette T{\o}nnes} and Lauritsen, {Mette Petri} and Freiesleben, {Nina la Cour}",
note = "Copyright {\circledC} 2016 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.",
year = "2016",
month = "6",
doi = "10.1016/j.rbmo.2016.03.006",
language = "English",
volume = "32",
pages = "563--83",
journal = "Reproductive BioMedicine Online",
issn = "1472-6483",
publisher = "Elsevier",
number = "6",

}

RIS

TY - JOUR

T1 - Mono-ovulation in women with polycystic ovary syndrome

T2 - Reproductive BioMedicine Online

AU - Birch Petersen, Kathrine

AU - Pedersen, Nina Gros

AU - Pedersen, Anette Tønnes

AU - Lauritsen, Mette Petri

AU - Freiesleben, Nina la Cour

N1 - Copyright © 2016 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.

PY - 2016/6

Y1 - 2016/6

N2 - Polycystic ovary syndrome (PCOS) affects 5-10% of women of reproductive age and is the most common cause of anovulatory infertility. The treatment approaches to ovulation induction vary in efficacy, treatment duration and patient friendliness. The aim was to determine the most efficient, evidence-based method to achieve mono-ovulation in women diagnosed with PCOS. Publications in English providing information on treatment, efficacy and complication rates were included until September 2015. Systematic reviews, meta-analyses and randomized controlled trials were favoured over cohort and retrospective studies. Clomiphene citrate is recommended as primary treatment for PCOS-related infertility. It induces ovulation in three out of four patients, the risk of multiple pregnancies is modest and the treatment is simple and inexpensive. Gonadotrophins are highly efficient in a low-dose step-up regimen. Ovulation rates are improved by lifestyle interventions in overweight women. Metformin may improve the menstrual cycle within 1-3 months, but does not improve the live birth rate. Letrozole is effective for ovulation induction, but is an off-label drug in many countries. Ovulation induction in women with PCOS should be individualized with regard to weight, treatment efficacy and patient preferences with the aim of achieving mono-ovulation and subsequently the birth of a singleton baby.

AB - Polycystic ovary syndrome (PCOS) affects 5-10% of women of reproductive age and is the most common cause of anovulatory infertility. The treatment approaches to ovulation induction vary in efficacy, treatment duration and patient friendliness. The aim was to determine the most efficient, evidence-based method to achieve mono-ovulation in women diagnosed with PCOS. Publications in English providing information on treatment, efficacy and complication rates were included until September 2015. Systematic reviews, meta-analyses and randomized controlled trials were favoured over cohort and retrospective studies. Clomiphene citrate is recommended as primary treatment for PCOS-related infertility. It induces ovulation in three out of four patients, the risk of multiple pregnancies is modest and the treatment is simple and inexpensive. Gonadotrophins are highly efficient in a low-dose step-up regimen. Ovulation rates are improved by lifestyle interventions in overweight women. Metformin may improve the menstrual cycle within 1-3 months, but does not improve the live birth rate. Letrozole is effective for ovulation induction, but is an off-label drug in many countries. Ovulation induction in women with PCOS should be individualized with regard to weight, treatment efficacy and patient preferences with the aim of achieving mono-ovulation and subsequently the birth of a singleton baby.

KW - Adult

KW - Anovulation

KW - Body Weight

KW - Clomiphene

KW - Female

KW - Fertility Agents, Female

KW - Gonadotropins

KW - Humans

KW - Infertility, Female

KW - Life Style

KW - Metformin

KW - Nitriles

KW - Overweight

KW - Ovulation

KW - Ovulation Induction

KW - Patient Safety

KW - Polycystic Ovary Syndrome

KW - Randomized Controlled Trials as Topic

KW - Reproductive Techniques, Assisted

KW - Retrospective Studies

KW - Triazoles

KW - Journal Article

KW - Review

U2 - 10.1016/j.rbmo.2016.03.006

DO - 10.1016/j.rbmo.2016.03.006

M3 - Review

VL - 32

SP - 563

EP - 583

JO - Reproductive BioMedicine Online

JF - Reproductive BioMedicine Online

SN - 1472-6483

IS - 6

ER -

ID: 177496229