Glial GABA Transporters as Modulators of Inhibitory Signalling in Epilepsy and Stroke

Publikation: Bidrag til bog/antologi/rapportBidrag til bog/antologiForskningfagfællebedømt

Maria E K Lie, Anas Al-Khawaja, Maria Damgaard, Anne S Haugaard, Arne Schousboe, Andrew N Clarkson, Petrine Wellendorph

Imbalances in GABA-mediated tonic inhibition are involved in several pathophysiological conditions. A classical way of controlling tonic inhibition is through pharmacological intervention with extrasynaptic GABAA receptors that sense ambient GABA and mediate a persistent GABAergic conductance. An increase in tonic inhibition may, however, also be obtained indirectly by inhibiting glial GABA transporters (GATs). These are sodium-coupled membrane transport proteins that normally act to terminate GABA neurotransmitter action by taking up GABA into surrounding astrocytes. The aim of the review is to provide an overview of glial GATs in regulating tonic inhibition, especially in epilepsy and stroke. This entails a comprehensive summary of changes known to occur in GAT expression levels and signalling following epileptic and ischemic insults. Further, we discuss the accumulating pharmacological evidence for targeting GATs in these diseases.
OriginalsprogEngelsk
TitelAdvances in Neurobiology
Antal sider31
Vol/bind16
Publikationsdato2017
Sider137-167
ISBN (Elektronisk)978-3-319-55769-4
DOI
StatusUdgivet - 2017
NavnAdvances in Neurobiology
ISSN2190-5215

ID: 186088753