Genome-wide association study identifies four loci associated with eruption of permanent teeth

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Frank Geller, Bjarke Feenstra, Hao Zhang, John R Shaffer, Thomas Hansen, Ann-Louise Esserlind, Heather A Boyd, Ellen A Nohr, Nicholas J Timpson, Ghazaleh Fatemifar, Lavinia Paternoster, David M Evans, Robert J Weyant, Steven M Levy, Mark Lathrop, George Davey Smith, Jeffrey C Murray, Jes Olesen, Thomas Mears Werge, Mary L Marazita & 2 andre Thorkild I A Sørensen, Mads Melbye

The sequence and timing of permanent tooth eruption is thought to be highly heritable and can have important implications for the risk of malocclusion, crowding, and periodontal disease. We conducted a genome-wide association study of number of permanent teeth erupted between age 6 and 14 years, analyzed as age-adjusted standard deviation score averaged over multiple time points, based on childhood records for 5,104 women from the Danish National Birth Cohort. Four loci showed association at P
TidsskriftP L o S Genetics
Udgave nummer9
Sider (fra-til)e1002275
StatusUdgivet - 1 sep. 2011

ID: 40186795