Effects of insulin detemir and NPH insulin on renal handling of sodium, fluid retention and weight in type 2 diabetic patients

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K V Hendriksen, Tonny Joran Jensen, P Oturai, B Feldt-Rasmussen

In type 2 diabetic patients, insulin detemir (B29Lys(ε-tetradecanoyl),desB30 human insulin) induces less weight gain than NPH insulin. Due to the proposed reduction of tubular action by insulin detemir, type 2 diabetic patients should have increased urinary sodium excretion, thereby reducing extracellular volume and body weight when changed from NPH insulin to insulin detemir.
OriginalsprogEngelsk
TidsskriftDiabetologia
Vol/bind55
Udgave nummer1
Sider (fra-til)46-50
Antal sider5
ISSN0012-186X
DOI
StatusUdgivet - 2012

ID: 48445263