Dopamine replacement modulates oscillatory coupling between premotor and motor cortical areas in Parkinson's disease

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Damian Marc Herz, Esther Florin, Mark Schram Christensen, Christiane Reck, Michael Thomas Barbe, Maike Karoline Tscheuschler, Marc Tittgemeyer, Hartwig Roman Siebner, Lars Timmermann

Efficient neural communication between premotor and motor cortical areas is critical for manual motor control. Here, we used high-density electroencephalography to study cortical connectivity in patients with Parkinson's disease (PD) and age-matched healthy controls while they performed repetitive movements of the right index finger at maximal repetition rate. Multiple source beamformer analysis and dynamic causal modeling were used to assess oscillatory coupling between the lateral premotor cortex (lPM), supplementary motor area (SMA), and primary motor cortex (M1) in the contralateral hemisphere. Elderly healthy controls showed task-related modulation in connections from lPM to SMA and M1, mainly within the γ-band (>30 Hz). Nonmedicated PD patients also showed task-related γ-γ coupling from lPM to M1, but γ coupling from lPM to SMA was absent. Levodopa reinstated physiological γ-γ coupling from lPM to SMA and significantly strengthened coupling in the feedback connection from M1 to lPM expressed as β-β as well as θ-β coupling. Enhancement in cross-frequency θ-β coupling from M1 to lPM was correlated with levodopa-induced improvement in motor function. The results show that PD is associated with an altered neural communication between premotor and motor cortical areas, which can be modulated by dopamine replacement.
OriginalsprogEngelsk
TidsskriftCerebral Cortex
Vol/bind24
Udgave nummer11
Sider (fra-til)2873-2883
Antal sider11
ISSN1047-3211
DOI
StatusUdgivet - 2014

Bibliografisk note

CURIS 2014 NEXS 313

ID: 46127169