Coordinated increase in skeletal muscle fiber area and expression of IGF-I with resistance exercise in elderly post-operative patients

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Standard

Coordinated increase in skeletal muscle fiber area and expression of IGF-I with resistance exercise in elderly post-operative patients. / Suetta, Charlotte; Clemmensen, Christoffer; Andersen, Jesper L; Magnusson, S Peter; Schjerling, Peter; Kjaer, Michael; Suetta, Charlotte Arneboe; Clemmensen, Christoffer; Andersen, Jesper L; Magnusson, S Peter; Schjerling, Peter; Kjaer, Michael.

I: Growth Hormone & IGF Research, Bind 20, Nr. 2, 01.04.2010, s. 134-40.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Suetta, C, Clemmensen, C, Andersen, JL, Magnusson, SP, Schjerling, P, Kjaer, M, Suetta, CA, Clemmensen, C, Andersen, JL, Magnusson, SP, Schjerling, P & Kjaer, M 2010, 'Coordinated increase in skeletal muscle fiber area and expression of IGF-I with resistance exercise in elderly post-operative patients' Growth Hormone & IGF Research, bind 20, nr. 2, s. 134-40. https://doi.org/10.1016/j.ghir.2009.11.005, https://doi.org/10.1016/j.ghir.2009.11.005

APA

Suetta, C., Clemmensen, C., Andersen, J. L., Magnusson, S. P., Schjerling, P., Kjaer, M., ... Kjaer, M. (2010). Coordinated increase in skeletal muscle fiber area and expression of IGF-I with resistance exercise in elderly post-operative patients. Growth Hormone & IGF Research, 20(2), 134-40. https://doi.org/10.1016/j.ghir.2009.11.005, https://doi.org/10.1016/j.ghir.2009.11.005

Vancouver

Suetta C, Clemmensen C, Andersen JL, Magnusson SP, Schjerling P, Kjaer M o.a. Coordinated increase in skeletal muscle fiber area and expression of IGF-I with resistance exercise in elderly post-operative patients. Growth Hormone & IGF Research. 2010 apr 1;20(2):134-40. https://doi.org/10.1016/j.ghir.2009.11.005, https://doi.org/10.1016/j.ghir.2009.11.005

Author

Suetta, Charlotte ; Clemmensen, Christoffer ; Andersen, Jesper L ; Magnusson, S Peter ; Schjerling, Peter ; Kjaer, Michael ; Suetta, Charlotte Arneboe ; Clemmensen, Christoffer ; Andersen, Jesper L ; Magnusson, S Peter ; Schjerling, Peter ; Kjaer, Michael. / Coordinated increase in skeletal muscle fiber area and expression of IGF-I with resistance exercise in elderly post-operative patients. I: Growth Hormone & IGF Research. 2010 ; Bind 20, Nr. 2. s. 134-40.

Bibtex

@article{66b162b0367c11df8ed1000ea68e967b,
title = "Coordinated increase in skeletal muscle fiber area and expression of IGF-I with resistance exercise in elderly post-operative patients",
abstract = "Hypertrophy of developing skeletal muscle involves stimulation by insulin-like growth factor-I (IGF-I), however, the role of IGF-I in adult muscle is less clarified. In the present study, the mRNA splice variants of IGF-I (IGF-IEa and MGF) and the changes in muscle fiber cross sectional area after 12weeks of training were studied in elderly post-operative patients. About 28 subjects, 14 men and 14 women (age 69, range 60-86 years) were randomized to unilateral resistance training (RT: 3/week), electrical stimulation (ES: 1h/day) or functional exercises (FE: 1h/day). The non-operated-side served as a within subject control. Muscle biopsies were obtained from the vastus lateralis of both limbs at +2d post-operative (baseline), at 5weeks and 12weeks post-surgery to analyze for changes in type 1 and type 2 muscle fiber area. Changes in expression levels of IGF-I mRNA isoforms were determined using real-time RT-PCR, normalized to the ribosomal protein large protein 0 (RPLP0) mRNA and presented relative to the control-side. At baseline there was no difference between the three groups in muscle fiber area or resting levels of IGF-IEa and MGF. RT resulted in a significant increase in muscle fiber area of type 1 (+17{\%}, p<0.05) and type 2 (+36{\%}, p<0.05) parallel to an increase in the expression of IGF-IEa and MGF, in contrast to ES and FE. The present study demonstrates that resistance training initiated in the acute post-operative phase is highly effective in increasing mean fiber area and in addition induces marked increases in the expression of IGF-I splice variants, supporting the idea that IGF-I is involved in regulating muscle hypertrophy.",
author = "Charlotte Suetta and Christoffer Clemmensen and Andersen, {Jesper L} and Magnusson, {S Peter} and Peter Schjerling and Michael Kjaer and Suetta, {Charlotte Arneboe} and Christoffer Clemmensen and Andersen, {Jesper L} and Magnusson, {S Peter} and Peter Schjerling and Michael Kjaer",
note = "Copyright {\circledC} 2009 Elsevier Ltd. All rights reserved.",
year = "2010",
month = "4",
day = "1",
doi = "10.1016/j.ghir.2009.11.005",
language = "English",
volume = "20",
pages = "134--40",
journal = "Growth Hormone & I G F Research",
issn = "1096-6374",
publisher = "Churchill Livingstone",
number = "2",

}

RIS

TY - JOUR

T1 - Coordinated increase in skeletal muscle fiber area and expression of IGF-I with resistance exercise in elderly post-operative patients

AU - Suetta, Charlotte

AU - Clemmensen, Christoffer

AU - Andersen, Jesper L

AU - Magnusson, S Peter

AU - Schjerling, Peter

AU - Kjaer, Michael

AU - Suetta, Charlotte Arneboe

AU - Clemmensen, Christoffer

AU - Andersen, Jesper L

AU - Magnusson, S Peter

AU - Schjerling, Peter

AU - Kjaer, Michael

N1 - Copyright © 2009 Elsevier Ltd. All rights reserved.

PY - 2010/4/1

Y1 - 2010/4/1

N2 - Hypertrophy of developing skeletal muscle involves stimulation by insulin-like growth factor-I (IGF-I), however, the role of IGF-I in adult muscle is less clarified. In the present study, the mRNA splice variants of IGF-I (IGF-IEa and MGF) and the changes in muscle fiber cross sectional area after 12weeks of training were studied in elderly post-operative patients. About 28 subjects, 14 men and 14 women (age 69, range 60-86 years) were randomized to unilateral resistance training (RT: 3/week), electrical stimulation (ES: 1h/day) or functional exercises (FE: 1h/day). The non-operated-side served as a within subject control. Muscle biopsies were obtained from the vastus lateralis of both limbs at +2d post-operative (baseline), at 5weeks and 12weeks post-surgery to analyze for changes in type 1 and type 2 muscle fiber area. Changes in expression levels of IGF-I mRNA isoforms were determined using real-time RT-PCR, normalized to the ribosomal protein large protein 0 (RPLP0) mRNA and presented relative to the control-side. At baseline there was no difference between the three groups in muscle fiber area or resting levels of IGF-IEa and MGF. RT resulted in a significant increase in muscle fiber area of type 1 (+17%, p<0.05) and type 2 (+36%, p<0.05) parallel to an increase in the expression of IGF-IEa and MGF, in contrast to ES and FE. The present study demonstrates that resistance training initiated in the acute post-operative phase is highly effective in increasing mean fiber area and in addition induces marked increases in the expression of IGF-I splice variants, supporting the idea that IGF-I is involved in regulating muscle hypertrophy.

AB - Hypertrophy of developing skeletal muscle involves stimulation by insulin-like growth factor-I (IGF-I), however, the role of IGF-I in adult muscle is less clarified. In the present study, the mRNA splice variants of IGF-I (IGF-IEa and MGF) and the changes in muscle fiber cross sectional area after 12weeks of training were studied in elderly post-operative patients. About 28 subjects, 14 men and 14 women (age 69, range 60-86 years) were randomized to unilateral resistance training (RT: 3/week), electrical stimulation (ES: 1h/day) or functional exercises (FE: 1h/day). The non-operated-side served as a within subject control. Muscle biopsies were obtained from the vastus lateralis of both limbs at +2d post-operative (baseline), at 5weeks and 12weeks post-surgery to analyze for changes in type 1 and type 2 muscle fiber area. Changes in expression levels of IGF-I mRNA isoforms were determined using real-time RT-PCR, normalized to the ribosomal protein large protein 0 (RPLP0) mRNA and presented relative to the control-side. At baseline there was no difference between the three groups in muscle fiber area or resting levels of IGF-IEa and MGF. RT resulted in a significant increase in muscle fiber area of type 1 (+17%, p<0.05) and type 2 (+36%, p<0.05) parallel to an increase in the expression of IGF-IEa and MGF, in contrast to ES and FE. The present study demonstrates that resistance training initiated in the acute post-operative phase is highly effective in increasing mean fiber area and in addition induces marked increases in the expression of IGF-I splice variants, supporting the idea that IGF-I is involved in regulating muscle hypertrophy.

U2 - 10.1016/j.ghir.2009.11.005

DO - 10.1016/j.ghir.2009.11.005

M3 - Journal article

VL - 20

SP - 134

EP - 140

JO - Growth Hormone & I G F Research

JF - Growth Hormone & I G F Research

SN - 1096-6374

IS - 2

ER -

ID: 18788531