Common variants on 8p12 and 1q24.2 confer risk of schizophrenia

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Yongyong Shi, Zhiqiang Li, Qi Xu, Ti Wang, Tao Li, Jiawei Shen, Fengyu Zhang, Jianhua Chen, Guoquan Zhou, Weidong Ji, Baojie Li, Yifeng Xu, Dengtang Liu, Peng Wang, Ping Yang, Benxiu Liu, Wensheng Sun, Chunling Wan, Shengying Qin, Guang He & 21 andre Stacy Steinberg, Sven Cichon, Thomas Werge, Engilbert Sigurdsson, Sarah Tosato, Aarno Palotie, Markus M Nöthen, Marcella Rietschel, Roel A Ophoff, David A Collier, Dan Rujescu, David St Clair, Hreinn Stefansson, Kari Stefansson, Jue Ji, Qingzhong Wang, Wenjin Li, Linqing Zheng, Hairong Zhang, Guoyin Feng, Lin He

Schizophrenia is a severe mental disorder affecting ~1% of the world population, with heritability of up to 80%. To identify new common genetic risk factors, we performed a genome-wide association study (GWAS) in the Han Chinese population. The discovery sample set consisted of 3,750 individuals with schizophrenia and 6,468 healthy controls (1,578 cases and 1,592 controls from northern Han Chinese, 1,238 cases and 2,856 controls from central Han Chinese, and 934 cases and 2,020 controls from the southern Han Chinese). We further analyzed the strongest association signals in an additional independent cohort of 4,383 cases and 4,539 controls from the Han Chinese population. Meta-analysis identified common SNPs that associated with schizophrenia with genome-wide significance on 8p12 (rs16887244, P = 1.27 × 10(-10)) and 1q24.2 (rs10489202, P = 9.50 × 10(-9)). Our findings provide new insights into the pathogenesis of schizophrenia.
OriginalsprogEngelsk
TidsskriftNature Genetics
Vol/bind43
Udgave nummer12
Sider (fra-til)1224-7
Antal sider4
ISSN1061-4036
DOI
StatusUdgivet - dec. 2011

ID: 40205079