Chemo-nociceptive signalling from the colon is enhanced by mild colitis and blocked by inhibition of transient receptor potential ankyrin 1 channels

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Martina Mitrovic, Anaid Shahbazian, Elisabeth Bock, Maria A Pabst, Peter Holzer

Transient receptor potential ankyrin 1 (TRPA1) channels are expressed by primary afferent neurones and activated by irritant chemicals including allyl isothiocyanate (AITC). Here we investigated whether intracolonic AITC causes afferent input to the spinal cord and whether this response is modified by mild colitis, morphine or a TRPA1 channel blocker.
TidsskriftBritish Journal of Pharmacology
Udgave nummer6
Sider (fra-til)1430-42
Antal sider13
StatusUdgivet - 1 jul. 2010

ID: 35292955