Chemo-nociceptive signalling from the colon is enhanced by mild colitis and blocked by inhibition of transient receptor potential ankyrin 1 channels
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Martina Mitrovic, Anaid Shahbazian, Elisabeth Bock, Maria A Pabst, Peter Holzer
Transient receptor potential ankyrin 1 (TRPA1) channels are expressed by primary afferent neurones and activated by irritant chemicals including allyl isothiocyanate (AITC). Here we investigated whether intracolonic AITC causes afferent input to the spinal cord and whether this response is modified by mild colitis, morphine or a TRPA1 channel blocker.
Originalsprog | Engelsk |
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Tidsskrift | British Journal of Pharmacology |
Vol/bind | 160 |
Udgave nummer | 6 |
Sider (fra-til) | 1430-42 |
Antal sider | 13 |
DOI | |
Status | Udgivet - 1 jul. 2010 |
ID: 35292955