Characteristics of 252 patients with bronchopulmonary neuroendocrine tumours treated at the Copenhagen NET Centre of Excellence

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

V. Grøndahl, T. Binderup, S. W. Langer, R. H. Petersen, K. Nielsen, A. Kjaer, B. Federspiel, U. Knigge

Background: Bronchopulmonary neuroendocrine tumours are divided into typical carcinoid (TC), atypical carcinoid (AC), large cell neuroendocrine carcinoma (LCNEC), and small cell lung cancer (SCLC). Aim: To thoroughly describe a cohort of 252 patients with TC, AC and LCNEC (SCLC excluded). Material and methods: Collection of data from 252 patients referred to and treated at Rigshospitalet 2008-2016. Data was collected from electronic patient files and our prospective NET database. Statistics were performed in SPSS. Results: 162 (64%)had TC, 29 (12%)had AC and 61 (24%)had LCNEC. Median age at diagnosis was 69 years (range: 19–89)with no difference between genders. Thoraco-abdominal CT was performed in all patients at diagnosis. FDG-PET/CT was performed in 207 (82%)at diagnosis and was positive in 95% of the entire cohort, with no difference between tumour types. Synaptophysin was positive in 98%, chromogranin A in 92% and CD56 in 97%. Mean Ki67 index was 5% in TC, 16% in AC and 69% in LCNEC (p < 0.001). Metastatic disease was found in 4% of TC, 27% of AC and 58% of LCNEC at time of initial diagnosis (p < 0.001). In total 179 patients (71%)underwent surgical resection; TC: 87%, AC: 72% and LCNEC: 28% (p < 0.001). Of the resected patients, 11 (6%)had recurrence. Five-year survival rate was 88% for TC, 63% for AC and 20% for LCNEC. Conclusion: In this comprehensive study of a cohort of 252 patients, one of the largest until date, with TC, AC and LCNEC, the gender distribution showed female predominance with 68%. FDG-PET/CT was positive in 95% of the patients independent of tumour type, which confirms that FDG-PET/CT should be a part of the preoperative work-up for TC, AC and LCNEC. Tumour type was the single most potent independent prognostic factor.

OriginalsprogEngelsk
TidsskriftLung Cancer
Vol/bind132
Sider (fra-til)141-149
Antal sider9
ISSN0169-5002
DOI
StatusUdgivet - 2019

ID: 226258599