Bioenergetic Changes during Differentiation of Human Embryonic Stem Cells along the Hepatic Lineage

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Branden M Hopkinson, Claus Desler Madsen, Mark Kalisz, Peter Siig Vestentoft, Lene Juel Rasmussen, Hanne Cathrine Bisgaard

Mitochondrial dysfunction has been demonstrated to result in premature aging due to its effects on stem cells. Nevertheless, a full understanding of the role of mitochondrial bioenergetics through differentiation is still lacking. Here we show the bioenergetics profile of human stem cells of embryonic origin differentiating along the hepatic lineage. Our study reveals especially the transition between hepatic specification and hepatic maturation as dependent on mitochondrial respiration and demonstrates that even though differentiating cells are primarily dependent on glycolysis until induction of hepatocyte maturation, oxidative phosphorylation is essential at all stages of differentiation.

OriginalsprogEngelsk
Artikelnummer5080128
TidsskriftOxidative Medicine and Cellular Longevity
Vol/bind2017
Antal sider11
ISSN1942-0900
DOI
StatusUdgivet - 2017

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