A Peptide Antagonist of ErbB Receptors, Inherbin3, Induces Neurite Outgrowth from Rat Cerebellar Granule Neurons Through ErbB1 Inhibition

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Ruodan Xu, Stanislava Pankratova, Søren Hofman Oliveira Christiansen, David Paul Drucker Woldbye, Anne Højland, Elisabeth Marianne Bock, Vladimir Berezin

rbB receptors not only function in cancer, but are also key developmental regulators in the nervous system. We previously identified an ErbB1 peptide antagonist, Inherbin3, that is capable of inhibiting tumor growth in vitro and in vivo. In this study, we found that inhibition of ErbB1 kinase activity and activation of ErbB4 by NRG-1β induced neurite extension, suggesting that ErbB1 and ErbB4 act as negative and positive regulators, respectively, of the neuritogenic response. Inherbin3, inhibited activation not only of ErbB1 but also of ErbB4 in primary neurons, strongly induced neurite outgrowth in rat cerebellar granule neurons, indicating that this effect mainly was due to inhibition of ErbB1 activation.
OriginalsprogEngelsk
TidsskriftNeurochemical Research
Vol/bind38
Udgave nummer12
Sider (fra-til)2550-8
Antal sider9
ISSN0364-3190
DOI
StatusUdgivet - 2013

ID: 105608139