Farmaceutisk fysisk og analytisk kemi
Universitetsparken 2, Bygning: 17-3-315c
2100 København Ø
My main research interest is the application of advanced analytical chemistry for the investigation of fate, biotransformation and cytotoxicity of metal-based drugs (e.g. cisplatin, oxaliplatin or new drug candidates) in biological systems. The research involves application of in vitro cancer cell systems as model systems. In terms of instrumentation this entails application of Inductively Coupled Plasma Mass Spectrometry (ICPMS) often coupled to separation techniques such as Capillary Electrophoresis (CE), Size Exclusion Chromatography (SEC) or High Pressure Liquid Chromatography (HPLC)
Other research interests are the application of ICPMS/ICPOES based instrumentation for determination of trace elements in drugs in the Pharmaceutical industry and the compliance of the techniques with current pharmacopeia requirements.
Papers with peer-review: 80; h-factor: 24
Development of ICP-MS methods for determination of trace element impurities in drug products. Development and validation of new methods to comply with Pharmacopeia requirements. Collaboration with Lundbeck.
Intracellular distribution of platinum following administration of cisplatin/oxaliplatin. Development of protocols for precise and accurate determination of platinum in cytosol, nucleus and mitochondria by ICPMS. Collaboration with Ian H. Lambert, Science, University of Copenhagen
Cellular uptake and stability of Metallacages. Development of analytical protocols to estimate uptake and stability of Pd2L4 metallacages in cells and tissue. Collaboration with Prof. Angela Casini, Cardiff University.
Undervisnings- og vejledningsområder
Pharmaceutical Analytical Chemistry (Bachelor)
Kemiske Principper (Bachelor)
7 PhD students and 21 master students, most recent (2018) master students are:
Mie Riisom; Development of ICPMS method for detmination of carbon and platinum including optimization af sample preparation procedures.
Emilie Rhiger; UPLC-MS for the quantitative determination of 13C-labelled glucose.