Jesper Langgaard Kristensen

Jesper Langgaard Kristensen

Professor MSO

Primære forskningsområder

Research interests

Generally medicinal chemistry and the development of new methodology for the construction of compound classes of relevance to medicinal chemistry. Using these tools we are trying to develop new probes and tools that will help us to elucidate the underlying mechanisms responsible for the regulation of different pharmacological targets: Ion channels, enzymes and GPCR’s.

Please see group web-page for more informantion.

 - Member of the Horizon2020 “Click-It” consortium receiving 6 mio. Euro (2015-2020) where we are developing a new imaging technology based on in-vivo click-chemistry.

 - Member of the Marie Curie ETN "AlphaSy" consortium receiving 4.1 mio. Euro (2018-2022) where we are developing a new imaging agents to diagnose Parkisons disease at an early stage.

 - Coordinator of the ETN-EID project SAFER receiving 1.3 mio. Euro (2017-2021). SAFER aims to identify functionally Selective Agonists for the 5-HT2A Serotonin Receptor.

Udvalgte publikationer

  1. Udgivet

    Enantioselective Total Synthesis of (+)-Dihydro-β-erythroidine

    Clementson, S., Jessing, M., Pedersen, H., Vital, P. & Kristensen, J. L., maj 2019, I : Journal of the American Chemical Society. 141, 22, s. 8783-8786

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

  2. Udgivet

    Dual Nicotinic Acetylcholine Receptor α4β2 Antagonists/α7 Agonists: Synthesis, Docking Studies, and Pharmacological Evaluation of Tetrahydroisoquinolines and Tetrahydroisoquinolinium Salts

    Crestey, F., Jensen, A. A., Soerensen, C., Magnus, C. B., Andreasen T., J., Peters, G. H. J. & Kristensen, J. L., 2018, I : Journal of Medicinal Chemistry. 61, s. 1719-1729

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

  3. Udgivet

    Hallucinogen-like effects of 2-([2-(4-cyano-2,5-dimethoxyphenyl) ethylamino]methyl)phenol (25CN-NBOH), a novel N-benzylphenethylamine with 100-fold selectivity for 5-HT2A receptors, in mice

    Fantegrossi, W. E., Gray, B. W., Bailey, J. M., Smith, D. A., Hansen, M. & Kristensen, J. L., 2015, I : Psychopharmacology. 232, 6, s. 1039-47 9 s.

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

  4. Udgivet

    Metabolic fate of hallucinogenic NBOMes

    Leth-Petersen, S., Gabel-Jensen, C., Gillings, N., Lehel, S., Hansen, H. D., Knudsen, G. M. & Kristensen, J. L., 2016, I : Chemical Research in Toxicology. 29, 1, s. 96–100 5 s.

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

  5. Udgivet

    Synthesis and structure-activity relationships of N-benzyl phenethylamines as 5-HT2A/2C agonists

    Hansen, M., Phonekeo, K., Paine, J. S., Leth-Petersen, S., Begtrup, M., Bräuner-Osborne, H. & Kristensen, J. L., 7 jan. 2014, I : A C S Chemical Neuroscience. 5, 3, s. 243-249 8 s.

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

ID: 1305029