Paul Robert Hansen

Paul Robert Hansen

Lektor

Medlem af:

    ORCID: 0000-0001-9357-8001

    Paul Robert Hansen earned his MS degree in Chemistry from the University of Copenhagen, Denmark in 1990. He was then a Research Assistant at the Department of Chemistry, Royal Veterinary and Agricultural University (KVL) for two years.
    From 1993-1994, he was a visiting Ph.D.-student in the laboratory of Professor George Barany at the Department of Chemistry, University of Minnesota
    In 1996, he received his Ph.D., from the Department of Chemistry, Royal Veterinary and Agricultural University, focusing on "New strategies in the synthesis of 2-acetamido-alpha–D–2-deoxy-glucopyranose O-Glycopeptides, neoglycoconjugates and photoreactive peptides" 

    In 1997, he joined the Department of Chemsitry, Royal Veterinary and Agricultural University, as an Assistant Professor of Bioorganic Chemistry. He became an Associate Professor in 2000. 
    In February 2012, he joined the Natural Products and Peptides Research Group, Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences (previously Faculty of Pharmaceutical Sciences), University of Copenhagen.

     

    Scientific achievements and Research interest:

    From 2001, he has been an independent scientist, heading his own research group first at IGM-Bioorganic Chemistry, Faculty of Life Sciences, University of Copenhagen and from 2012 at the Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen. PRH has an extensive documented experience in the field of peptide medicinal chemistry. PRHs research efforts mainly lie within i) peptide-based antibiotics, ii) peptides as probes in immunology and Calcitonin gene-related peptide analogues for treatment of glaucoma. PRH has co-authored 125+ scientific publications in the field of peptide chemistry/bioorganic chemistry. He is the editor of Methods in Molecular Biology: Antimicrobial Peptides published in 2017. Furthermore, PRH is Editorial Board Member for Antibiotics and Reviewer for Innovation Fund Denmark etc, AAC, J. Med. Chem. etc.

    Research management:

    From 2008-2013, PRH was a member of EPI-EXPOSE funded by the Danish Advanced Technology Foundation, Work package leader and member of steering commitee). From 2010-2015, he was a member of DANCARD (Danish Center for Antibiotic Research and Development) an interdisciplinary collaboration funded the Danish Council for Strategic Research. From 2012-2016, PRH was a partner in FP7-PEOPLE-2011-ITN TRAIN-ASAP (“Training Research AImed at Novel Antibacterial Strategies in Animals and People”, Work package leader and member of steering commitee). Furthermore, he was a partner in University of Copenhagen Research Centre for Control of Antibiotic Resistance UC-CARE.Currently and “Antimicrobial peptides seen by neutrons” funded by Nordforsk. 

    Udvalgte publikationer

    1. Udgivet

      C-locked analogs of the antimicrobial peptide BP214

      Andersen, I. K. L., Thomsen, T. T., Rashid, J., Bobak, Thomas Rønnemoes, Oddo, A., Franzyk, Henrik, Løbner-Olesen, Anders & Hansen, Paul Robert, 2022, I: Antibiotics. 11, 8, 10 s., 1080.

      Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

    2. Udgivet

      Cyclic N-Locked Indolicidin Analogues with Antimicrobial Activity: Effect of Ring Size and Fatty Acid Acylation

      Lone, A. B. N., Nielsen, J. E., Thulstrup, Peter Waaben, Lund, R., Hansen, Paul Robert & Jenssen, H., 2022, I: European Journal of Medicinal Chemistry Reports. 6, 7 s., 100080.

      Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

    3. Udgivet

      Novel Cyclic Lipopeptide Antibiotics: Effects of Acyl Chain Length and Position

      Jensen, S. K., Thomsen, T. T., Oddo, A., Franzyk, Henrik, Løbner-Olesen, Anders & Hansen, Paul Robert, 2020, I: International Journal of Molecular Sciences . 21, 16, 18 s., 5829.

      Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

    4. Udgivet

      Analogues of a Cyclic Antimicrobial Peptide with a Flexible Linker Show Promising Activity Against Pseudomonas aeruginosa and Staphylococcus aureus

      Thomsen, T. T., Mendel, H. C., Al-Mansour, W., Oddo, A., Løbner-Olesen, Anders & Hansen, Paul Robert, 2020, I: Antibiotics. 9, 7, 13 s., 366.

      Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

    5. Udgivet

      Correlation between hemolytic activity, cytotoxicity and systemic in vivo toxicity of synthetic antimicrobial peptides

      Greco, I., Molchanova, N., Holmedal, E., Jenssen, H., Hummel, B. D., Watts, J. L., Håkansson, J., Hansen, Paul Robert & Svenson, J., 2020, I: Scientific Reports. 10, 13 s., 13206.

      Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

    6. Udgivet

      Alternating Cationic-Hydrophobic Peptide/Peptoid Hybrids: Influence of Hydrophobicity on Antibacterial Activity and Cell Selectivity

      Frederiksen, N., Hansen, Paul Robert, Zabicka, D., Tomczak, M., Urbas, M., Domraceva, I., Björkling, Fredrik & Franzyk, Henrik, 2020, I: ChemMedChem. 15, 24, s. 2544-2561

      Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

    7. Udgivet

      Fluorescent analogues of Human α-Calcitonin Gene-Related Peptide with vasodilator potency

      Zhu, J., Pedersen, M. D., Ahmed, L. S., Abdolalizadeh, B., Grell, A., Berg, Jais Oliver, Thulstrup, Peter Waaben, Franzyk, Henrik, Edvinsson, L., Sams, A., Sheykhzade, Majid & Hansen, Paul Robert, 2020, I: International Journal of Molecular Sciences (Online). 21, 4, s. 1-15 15 s., 1343.

      Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

    8. Udgivet

      Structure-Activity Study of an All-D Antimicrobial Octapeptide D2D

      Lone, A., Thomsen, T. T., Nielsen, J. E., Thulstrup, Peter Waaben, Klitgaard, R. N., Løbner-Olesen, Anders, Lund, R., Jenssen, H. & Hansen, Paul Robert, 2019, I: Molecules. 24, 24, 17 s., 4571.

      Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

    9. Udgivet

      Peptides, antibodies, peptide antibodies and more

      Trier, N., Hansen, Paul Robert & Houen, G., 11 nov. 2019, I: International Journal of Molecular Sciences (Online). 20, 22 s., 6289.

      Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt

    10. Udgivet

      Peptide/Peptoid Hybrid Oligomers: The Influence of Hydrophobicity and Relative Side-Chain Length on Antibacterial Activity and Cell Selectivity

      Frederiksen, N., Hansen, Paul Robert, Björkling, Fredrik & Franzyk, Henrik, 4 dec. 2019, I: Molecules (Print Archive Edition). 24, 18 s., 4429.

      Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

    11. Udgivet

      Fine mapping of glutamate decarboxylase 65 epitopes reveals dependency of hydrophobic amino acids for specific interactions

      Valdarnini, N., Holm, B., Hansen, Paul Robert, Rovero, P., Houen, G. & Trier, N. H., 2019, I: International Journal of Molecular Sciences (Online). 20, 13 s., 2909.

      Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

    12. Udgivet

      A Biophysical Study of the Interactions between the Antimicrobial Peptide Indolicidin and Lipid Model Systems

      Nielsen, J. E., Lind, T. K., Lone, A., Gerelli, Y., Hansen, Paul Robert, Jenssen, H., Cárdenas, M. & Lund, R., 2019, I: B B A - Biomembranes. 1861, 7, s. 1355-1364

      Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

    13. Udgivet

      Antimicrobial Activity of α-Peptide/β-Peptoid Lysine-Based Peptidomimetics Against Colistin-Resistant Pseudomonas aeruginosa Isolated From Cystic Fibrosis Patients

      Molchanova, N., Wang, H., Hansen, Paul Robert, Høiby, Niels, Nielsen, Hanne Mørck & Franzyk, Henrik, 2019, I: Frontiers in Microbiology. 10, 9 s., 275.

      Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

    14. Udgivet

      Characterization, mechanism of action and optimization of activity of a novel peptide-peptoid hybrid against bacterial pathogens involved in canine skin infections

      Greco, I., Emborg, A., Jana, B., Molchanova, N., Oddo, A., Damborg, Peter Panduro, Guardabassi, Luca & Hansen, Paul Robert, 2019, I: Scientific Reports. 9, 12 s., 3679.

      Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

    15. Udgivet

      Specificity of anti-citrullinated protein antibodies in rheumatoid arthritis

      Trier, N., Holm, B. E., Hansen, Paul Robert, Slot, O., Locht, H. & Houen, G., 2019, I: Antibodies. 8, 2, 10 s., 37.

      Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

    16. Udgivet

      Structure-activity study, characterization and mechanism of action of an antimicrobial peptoid D2 and its D- and L-peptide analogues

      Greco, I., Hansen, J. E., Jana, B., Molchanova, N., Oddo, A., Thulstrup, Peter Waaben, Damborg, Peter Panduro, Guardabassi, Luca & Hansen, Paul Robert, 2019, I: Molecules. 24, 6, 16 s., 1121.

      Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

    17. Udgivet

      Biopolymer nanogels improve antibacterial activity and safety profile of a novel lysine-based α-peptide/β-peptoid peptidomimetic

      Kłodzińska, S. N., Molchanova, N., Franzyk, Henrik, Hansen, Paul Robert, Damborg, Peter Panduro & Nielsen, Hanne Mørck, jul. 2018, I: European Journal of Pharmaceutics and Biopharmaceutics. 128, s. 1-9 9 s.

      Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

    18. Udgivet

      Fmoc Solid-Phase Synthesis of Human a-Calcitonin Gene- Related Peptide and Two Carboxyfluorescein-labeled Analogs

      Ahmed, L. S., Abdolalizadeh, B., Sheykhzade, Majid & Hansen, Paul Robert, 11 feb. 2018.

      Publikation: Konferencebidrag › Poster › Forskning › fagfællebedømt

    19. Udgivet

      In Vitro ADME Properties of Two Novel Antimicrobial Peptoid-Based Compounds as Potential Agents against Canine Pyoderma

      Greco, I., Hummel, B. D., Vasir, J., Watts, J. L., Koch, J., Hansen, J. E., Nielsen, Hanne Mørck, Damborg, Peter Panduro & Hansen, Paul Robert, 10 mar. 2018, I: Molecules. 23, 3, 15 s., 630.

      Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

    20. Udgivet

      Fluorinated antimicrobial lysine-based peptidomimetics with activity against methicillin-resistant Staphylococcus pseudintermedius

      Molchanova, N., Hansen, Paul Robert, Damborg, Peter Panduro & Franzyk, Henrik, 2018, I: Journal of Peptide Science. 24, 7, 8 s., e3098.

      Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

    21. Udgivet

      Linear peptidomimetics as potent antagonists of Staphylococcus aureus agr quorum sensing

      Karathanasi, G., Bojer, Martin Saxtorph, Baldry, M., Johannessen, B. A., Wolff, S., Greco, I., Kilstrup, M., Hansen, Paul Robert & Ingmer, Hanne, 2018, I: Scientific Reports. 8, 1, 11 s., 3562.

      Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

    22. Udgivet

      Review on abyssomicins: Inhibitors of the chorismate pathway and folate biosynthesis

      Sadaka, C., Ellsworth, E., Hansen, Paul Robert, Ewin, R., Damborg, Peter Panduro & Watts, J. L., 2018, I: Molecules. 23, 6, 25 s., 1371.

      Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt

    23. Udgivet

      The prototypical proton-coupled oligopeptide transporter YdgR from Escherichia coli facilitates chloramphenicol uptake into bacterial cells

      Prabhala, B. K., Aduri, N. G., Sharma, N., Shaheen, A., Sharma, A., Iqbal, M., Hansen, Paul Robert, Brasen, C., Gajhede, Michael, Rahman, M. & Mirza, Osman Asghar, 2018, I: The Journal of Biological Chemistry. 293, s. 1007-1017

      Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

    24. Udgivet

      Advances in development of antimicrobial peptidomimetics as potential drugs

      Molchanova, N., Hansen, Paul Robert & Franzyk, Henrik, 28 aug. 2017, I: Molecules. 22, 9, 60 s., 1430.

      Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt

    25. Udgivet

      Broadening CD4(+) and CD8(+) T Cell Responses against Hepatitis C Virus by Vaccination with NS3 Overlapping Peptide Panels in Cross-Priming Liposomes

      Filskov, J., Mikkelsen, M., Hansen, Paul Robert, Christensen, Jan Pravsgaard, Thomsen, Allan Randrup, Andersen, P., Bukh, Jens & Agger, E., jul. 2017, I: Journal of Virology. 91, 14, 18 s., e00130-17.

      Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

    26. Udgivet

      Several hPepT1-transported drugs are substrates of the Escherichia coli proton-coupled oligopeptide transporter YdgR

      Prabhala, B. K., Aduri, N. G., Iqbal, M., Rahman, M., Gajhede, Michael, Hansen, Paul Robert & Mirza, Osman Asghar, 16 feb. 2017, I: Research in Microbiology. 168, 5, s. 443-449

      Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

    27. Udgivet

      Methods in Molecular Biology: Antimicrobial Peptides Methods and Protocols

      Hansen, Paul Robert (red.), 1 jan. 2017, Springer. 439 s.

      Publikation: Bog/antologi/afhandling/rapport › Bog › Forskning › fagfællebedømt

    28. Udgivet

      Chemical Synthesis of Antimicrobial Peptides.

      Münzker, L., Oddo, A. & Hansen, Paul Robert, 2017, Chemical Synthesis of Antimicrobial Peptides: Münzker L, Oddo A, Hansen PR. Methods Mol Biol. 2017; . Hansen, P. R. (red.). Springer, Bind 1548. s. 35-49.

      Publikation: Bidrag til bog/antologi/rapport › Bidrag til bog/antologi › Forskning › fagfællebedømt

    29. Udgivet

      Lysine-Based α-peptide/β-peptoid peptidomimetics: Influence of hydrophobicity, fluorination and distribution of cationic charge on antimicrobial activity and cytotoxicity

      Molchanova, N., Hansen, Paul Robert, Damborg, Peter Panduro, Nielsen, Hanne Mørck & Franzyk, Henrik, 2017, I: ChemMedChem. 12, s. 312-318 7 s.

      Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

    30. Udgivet

      Hemolytic Activity of Antimicrobial Peptides

      Oddo, A. & Hansen, Paul Robert, 2017, Methods in molecular biology. Hansen, P. R. (red.). Springer, Bind 1548. s. 427-435

      Publikation: Bidrag til bog/antologi/rapport › Bidrag til bog/antologi › Forskning › fagfællebedømt

    31. Udgivet

      Structure-activity relationship studies of lysine-based α-peptide/β-peptoid antimicrobial peptidomimetics

      Molchanova, N., Hansen, Paul Robert, Damborg, Peter Panduro & Franzyk, Henrik, 2017. 1 s.

      Publikation: Konferencebidrag › Poster › Forskning › fagfællebedømt

    32. Udgivet

      An amphipathic undecapeptide with all D-amino acids shows promising activity against colistin-resistant strains of Acinetobacter baumannii and a dual mode of action

      Oddo, A., Thomsen, T. T., Kjelstrup, S., Gorey, C., Franzyk, Henrik, Frimodt-Møller, N., Løbner-Olesen, Anders & Hansen, Paul Robert, 2016, I: Antimicrobial Agents and Chemotherapy. 60, 1, s. 592-599 8 s.

      Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

    33. Udgivet

      Modulation of backbone flexibility for effective dissociation of antibacterial and hemolytic activity in cyclic peptides

      Oddo, A., Thomsen, T. T., Britt, H. M., Løbner-Olesen, Anders, Thulstrup, Peter Waaben, Sanderson, J. M. & Hansen, Paul Robert, 2016, I: ACS Medicinal Chemistry Letters. 7, 8, s. 741-745 5 s.

      Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

    34. Udgivet

      Roles of hydrophobicity, fluorination and distribution of cationic residues in α-peptide/β-peptoids for antibacterial and hemolytic properties

      Molchanova, N., Hansen, Paul Robert, Damborg, Peter Panduro & Franzyk, Henrik, 2016. 1 s.

      Publikation: Konferencebidrag › Poster › Forskning

    35. Udgivet

      Amphibian antimicrobial peptide fallaxin analogue FL9 affects virulence gene expression and DNA replication in Staphylococcus aureus

      Gottschalk, S., Gottlieb, C. T., Vestergaard, M., Hansen, Paul Robert, Gram, L., Ingmer, Hanne & Thomsen, Line Elnif, 1 dec. 2015, I: Journal of Medical Microbiology. 64, 12, s. 1504-1513 10 s.

      Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

    36. Udgivet

      Short linear peptide-peptoid hybrids as potential antimicrobial drugs: Abstract for the 24th American Peptide Symposium

      Greco, I., Damborg, Peter Panduro, Jana, B. & Hansen, Paul Robert, 1 jun. 2015.

      Publikation: Konferencebidrag › Konferenceabstrakt til konference › Forskning › fagfællebedømt

    37. Udgivet

      Antibodies with specificity for native and denatured forms of ovalbumin differ in reactivity between enzyme-linked immunosorbent assays.

      Holm, B. E., Bergmann, A. C., Hansen, Paul Robert, Koch, C., Houen, G. & Trier, N. H., 1 feb. 2015, I: A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica. 123, 2, s. 136–145 10 s.

      Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

    38. Udgivet

      An ANOVA-based model to identify the optimal antimicrobial peptide in a combination matrix

      Munk, J. K., Ritz, C., Fliedner, F. P., Frimodt-Moller, N. & Hansen, Paul Robert, 2015.

      Publikation: Konferencebidrag › Konferenceabstrakt til konference › Forskning › fagfællebedømt

    39. Udgivet

      Antimicrobial activities of synthetic anoplin analogues against methicillin-resistant Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, vancomycin-resistant Enterococcus faecium and Candida albicans

      Munk, J. K., Uggerhøj, L. E., Poulsen, T. J., Frimodt-Moller, N., Nyberg, N., Wimmer, R. & Hansen, Paul Robert, 2015.

      Publikation: Konferencebidrag › Konferenceabstrakt til konference › Forskning › fagfællebedømt

    40. Udgivet

      Characterization of synthetic peptides by mass spectrometry

      Prabhala, B. K., Mirza, Osman Asghar, Højrup, P. & Hansen, Paul Robert, 2015, Methods in Molecular Biology: Peptide Antibiodies. Springer, s. 77-82

      Publikation: Bidrag til bog/antologi/rapport › Bidrag til bog/antologi › Forskning › fagfællebedømt

    41. Udgivet

      Contribution of peptide backbone to Anti-citrulline-dependent antibody reactivity

      Trier, N. H., Dam, C., Olsen, D., Hansen, Paul Robert & Houen, G., 2015, I: P L o S One. s. 1-12 12 s., 0144707.

      Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

    42. Udgivet

      Correlation between centromere protein-F autoantibodies and cancer analyzed by enzyme-linked immunosorbent assay

      Welner, S., Trier, N. H., Morten Frisch, M., Locht, H., Hansen, Paul Robert & Houen, G., 2013, I: Molecular Cancer. 12, 1, 95.

      Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

    43. Udgivet

      Efficient, regioselective ring-opening of activated aziridine-2-carboxylates with [18F]fluoride

      Schjøth-Eskesen, C., Hansen, Paul Robert, Kjær, Andreas & Gillings, N., 2015, I: ChemistryOpen. 4, 1, s. 65–71 7 s.

      Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

    44. Udgivet

      Fmoc Solid-Phase Peptide Synthesis

      Hansen, Paul Robert & Oddo, A., 2015, Methods in Molecular Biology: Peptide Antibodies. Bind 1348. s. 33-50 18 s.

      Publikation: Bidrag til bog/antologi/rapport › Bidrag til bog/antologi › Forskning › fagfællebedømt

    45. Udgivet

      Identifying immunogenic CD4+ T-cell epitopes of Myeloid cell leukemia 1 using overlapping 20-mer peptides spanning the whole protein.

      Woodworth, J. S., Agger, E. M. & Hansen, Paul Robert, 2015, Proceedings of the 24th American Peptide Symposium Ved Srivastava, Andrei Yudin, and Michal Lebl (Editors) American Peptide Society. s. 262-63 2 s.

      Publikation: Bidrag til bog/antologi/rapport › Konferencebidrag i proceedings › Forskning › fagfællebedømt

    46. Udgivet

      Novel classes of antimicrobials in veterinary medicine: Characterizing peptoids as topical agents for dog skin infections

      Greco, I., Damborg, Peter Panduro, Guardabassi, Luca, Vasir, J., Watts, J., Hummel, B. D. & Hansen, Paul Robert, 2015.

      Publikation: Konferencebidrag › Konferenceabstrakt til konference › Forskning › fagfællebedømt

    47. Udgivet

      Novel compounds with selective antimicrobial activity against Staphylococcus pseudintermedius and Pseudomonas aeruginosa causing pyoderma in dogs

      Greco, I., Emborg, A., Oddo, A., Damborg, Peter Panduro, Guardabassi, Luca & Hansen, Paul Robert, 2015.

      Publikation: Konferencebidrag › Konferenceabstrakt til konference › Forskning › fagfællebedømt

    48. Udgivet

      Peptide Macrocycles Featuring a Backbone Secondary Amine: A Convenient Strategy for the Synthesis of Lipidated Cyclic and Bicyclic Peptides on Solid Support

      Oddo, A., Münzker, L. & Hansen, Paul Robert, 2015, I: Organic Letters. 17, 10, s. 2502-2505 4 s.

      Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

    49. Udgivet

      Peptide-Carrier Conjugation: Methods in Molecular Biology

      Hansen, Paul Robert, 2015, Methods in Molecular Biology: Peptide Antibodies. Bind 1348. s. 51-57 7 s.

      Publikation: Bidrag til bog/antologi/rapport › Bidrag til bog/antologi › Forskning › fagfællebedømt

    50. Udgivet

      Rational Design of alpha-helical antimicrobial peptides: DOs and DON’Ts

      Uggerhøj, L. E., Poulsen, T. J., Munk, J. K., Fredborg, M., Sondergaard, T. E., Frimodt-Møller, N., Hansen, Paul Robert & Wimmer, R., 2015, I: ChemBioChem. 16, 2, s. 242–253 12 s.

      Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

    51. Udgivet

      Solid-Phase Peptide Synthesis of Human alfa-Calcitonin Gene-Related Peptide and Two Fluorescent Analogs.

      Fuente-Moreno, M., Oddo, A., Sheykhzade, Majid, Pickering, Darryl S & Hansen, Paul Robert, 2015, Proceedings of the 24th American Peptide Symposium . 2 s.

      Publikation: Bidrag til bog/antologi/rapport › Konferencebidrag i proceedings › Forskning › fagfællebedømt

    52. Udgivet

      Structure-Activity Relationship Study of Lysine-Based Antimicrobial α-Peptide/β-Peptoid Oligomers

      Molchanova, N., Hansen, Paul Robert & Franzyk, Henrik, 2015.

      Publikation: Konferencebidrag › Poster › Forskning

    53. Udgivet

      The effect of glycine replacement with flexible ω-amino acids on the antimicrobial and haemolytic activity of an amphipathic cyclic heptapeptide

      Oddo, A., Nyberg, N., Frimodt-Møller, N., Thulstrup, Peter Waaben & Hansen, Paul Robert, 2015, I: European Journal of Medicinal Chemistry. 102, s. 574-581 8 s.

      Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

    54. Udgivet

      [64Cu]-Labelled Trastuzumab: Optimisation of Labelling by DOTA and NODAGA Conjugation and Initial Evaluation in Mice

      Schjøth-Eskesen, C., Nielsen, Carsten Haagen, Heissel, S., Højrup, P., Hansen, Paul Robert, Gillings, N. & Kjær, A., 2015, I: Journal of Labelled Compounds and Radiopharmaceuticals. 58, 6, s. 227-33 7 s.

      Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

    55. Udgivet

      Pepping up Antibiotics: Industry and academia are turning to antimicrobial peptides and their relatives to find new antibiotics, Andy Extance discovers..

      Hansen, Paul Robert, 1 okt. 2014, Chemistry World.

      Publikation: Andet › Andet bidrag › Forskning

    56. Udgivet

      AMP mimics with bactericidal activity against Staphylococci and Pseudomonas as novel drugs for topical use in veterinary medicine

      Greco, I., Damborg, Peter Panduro, Guardabassi, Luca, Nielsen, Hanne Mørck & Hansen, Paul Robert, 4 jun. 2014.

      Publikation: Konferencebidrag › Poster › Forskning › fagfællebedømt

    57. Udgivet

      Ring flexibility as a key design feature for cyclic antimicrobial peptides

      Oddo, A., Frimodt-Møller, N. & Hansen, Paul Robert, 4 jun. 2014.

      Publikation: Konferencebidrag › Poster › Forskning › fagfællebedømt

    58. Udgivet

      Identification and fine mapping of a linear B cell epitope of human vimentin

      Dam, C. E., Houen, G., Hansen, Paul Robert & Trier, N., 2014, I: Scandinavian Journal of Clinical & Laboratory Investigation. 74, 6, s. 506-514 9 s.

      Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

    59. Udgivet

      Identification of a linear epitope recognized by a monoclonal antibody directed to the heterogeneous nucleoriboprotein A2

      Tronstrøm, J., Dragborg, A. H., Hansen, Paul Robert, Houen, G. & Trier, N. H., 2014, I: Protein and Peptide Letters. 21, 1, s. 25-31 7 s.

      Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

    60. Udgivet

      Invited Lecture: From Host Defence Peptides to New Antibiotics

      Hansen, Paul Robert, 2014.

      Publikation: Konferencebidrag › Konferenceabstrakt til konference › Forskning

    61. Udgivet

      Novel method to identify the optimal antimicrobial peptide in a combination matrix, using anoplin as an example

      Munk, J., Ritz, C., Fliedner, F. P., Frimodt-Møller, N. & Hansen, Paul Robert, 2014, I: Antimicrobial Agents and Chemotherapy. 58, 2, s. 1063-1070 8 s.

      Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

    62. Udgivet

      Protective CD4 T cells targeting cryptic epitopes of Mycobacterium tuberculosis resist infection-driven terminal differentiation

      Woodworth, J., Aagaard, C., Hansen, Paul Robert, Cassidy, J., Agger, E. M. & Andersen, P., 2014, I: The Journal of Immunology. 192, 7, s. 3247-58

      Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

    63. Udgivet

      Structural features of peptoid-peptide hybrids in lipid-water interfaces

      Uggerhøj, L. E., Munk, J. K., Hansen, Paul Robert, Güntert, P. & Wimmer, R., 2014, I: F E B S Letters. 588, 17, s. 3291–3297 8 s.

      Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

    64. Udgivet

      A Novel Peptide-Peptoid Hybrid Active Against MRSP Skin Infections

      Greco, I., Damborg, Peter Panduro, Guardabassi, Luca & Hansen, Paul Robert, 4 nov. 2013.

      Publikation: Konferencebidrag › Poster › Forskning › fagfællebedømt

    65. Udgivet

      De novo design of novel cyclic antimicrobial peptides

      Oddo, A., Frimodt-Moller, N. & Hansen, Paul Robert, 7 jul. 2013.

      Publikation: Konferencebidrag › Poster › Forskning › fagfællebedømt

    66. Udgivet

      Peptide-peptoid hybrids active against methicillin-resistant Staphylococci and Pseudomonas aeruginosa

      Greco, I., Damborg, Peter Panduro, Guardabassi, Luca, Nielsen, Hanne Mørck & Hansen, Paul Robert, 7 jul. 2013.

      Publikation: Konferencebidrag › Poster › Forskning › fagfællebedømt

    67. Udgivet

      A Minimal Labor Approach to Identifying the Optimal Anoplin Analog using ANOVA.

      Munk, J., Ritz, C., Petrine Fliedner, F., Frimodt-Møller, N. & Hansen, Paul Robert, 2013, Proceedings of the 23rd American Peptide Symposium.

      Publikation: Bidrag til bog/antologi/rapport › Konferencebidrag i proceedings › Forskning › fagfællebedømt

    68. Udgivet

      Cyclic peptide inhibitors of the β-sliding clamp in Staphylococcus aureus

      Kjelstrup, S., Hansen, P. M. P., Thomsen, Line Elnif, Hansen, Paul Robert & Løbner-Olesen, Anders, 2013, I: P L o S One. 8, 9, 13 s., e72273.

      Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

    69. Udgivet

      Identification and mapping of a linear epitope of centromere protein F using monoclonal antibodies

      Welner, S., Trier, N. H., Houen, G. & Hansen, Paul Robert, 2013, I: Journal of Peptide Science. 19, 2, s. 95-101

      Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

    70. Udgivet

      Synthesis of antimicrobial peptoids

      Hansen, Paul Robert & Munk, J., 2013, Peptide synthesis and applications. 2nd udg. Bind 1047. s. 151-159 (Methods in Molecular Biology).

      Publikation: Bidrag til bog/antologi/rapport › Bidrag til bog/antologi › Forskning

    71. Udgivet

      Synthetic analogs of anoplin show improved antimicrobial activities

      Munk, J., Uggerhøj, L. E., Poulsen, T. J., Frimodt-Møller, N., Wimmer, R., Nyberg, N. T. & Hansen, Paul Robert, 2013, I: Journal of Peptide Science. 19, 11, s. 669-75

      Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

    72. Udgivet

      The Structure of the Central Side Chain is Crucial for Anoplin Hemolytic Activity

      Munk, J., Thøgersen, L., Uggerhøj, L. E., Wimmer, R., Frimodt-Møller, N., Lindorff-Larsen, Kresten & Hansen, Paul Robert, 2013, Proceedings of the 23rd American Peptide Symposium. Lebl, M. (red.). American Peptide Society

      Publikation: Bidrag til bog/antologi/rapport › Konferencebidrag i proceedings › Forskning › fagfællebedømt

    73. Udgivet

      The antimicrobial lysine-peptoid hybrid LP5 inhibits DNA replication and induces the SOS response in Staphylococcus aureus

      Gottschalk, S., Ifrah, D., Søndergaard, S. L., Gottlieb, C. T., Cohn, M. T., Hiasa, H., Hansen, Paul Robert, Gram, L., Ingmer, Hanne & Thomsen, Line Elnif, 2013, I: B M C Microbiology. 13, 8 s., 192.

      Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

    74. Udgivet

      Cross-reactivity of a human IgG1 anticitrullinated fibrinogen monoclonal antibody to a citrullinated profilaggrin peptide

      Trier, N. H., Leth, M. L., Hansen, Paul Robert & Houen, G., 31 dec. 2012, I: Protein Science. 21, 12, s. 1929-1941

      Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

    75. Udgivet

      Cytotoxicity and in vivo efficacy of a novel antimicrobial peptoid against Staphylococcus pseudintermedius

      Damborg, Peter Panduro, Skindersø, M. E., Hansen, Paul Robert, Bahnsen, J. S., Nielsen, Hanne Mørck & Guardabassi, Luca, aug. 2012.

      Publikation: Konferencebidrag › Poster › Forskning › fagfællebedømt

    76. Udgivet

      Antimikrobielle peptider: et nyt våben mod multiresistente bakterier

      Munk, J., Hansen, Paul Robert & Franzyk, Henrik, 2012, I: Lægemiddelforskning. 2012, s. 9-11

      Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Formidling

    77. Udgivet

      Fine mapping of a monoclonal antibody to the N-Methyl D-aspartate receptor reveals a short linear epitope

      Amrutkar, S. D., Trier, N. H., Hansen, Paul Robert & Houen, G., 2012, I: Journal of Peptide Science. 98, 6, s. 567-575 9 s.

      Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

    78. Udgivet

      Identification of continuous epitopes of HuD antibodies related to paraneoplastic diseases/small cell lung cancer

      Trier, N. H., Hansen, Paul Robert, Vedeler, C. A., Somnier, F. E. & Houen, G., 2012, I: Journal of Neuroimmunology. 243, 1, s. 25-33 9 s.

      Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

    79. Udgivet

      Production and characterization of peptide antibodies

      Trier, N. H., Hansen, Paul Robert & Houen, G., 2012, I: Methods. 56, 2, s. 136-144 9 s.

      Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

    80. Udgivet

      Peptide Antibody Reactivity to Homologous Regions in Glutamate Decarboxylase Isoforms and Coxsackievirus B4 P2C

      Trier, N. H., Valdarnini, N., Fanelli, I., Rovero, P., Hansen, Paul Robert, Schafer, C., Ciplys, E., Slibinskas, R., Pociot, F., Friis, T. & Houen, G., 2022, I: International Journal of Molecular Sciences. 23, 8, 16 s., 4424.

      Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

    81. Udgivet

      Production and characterization of peptide antibodies to the C-terminal of frameshifted calreticulin associated with myeloproliferative diseases

      Mughal , F. P., Bergmann , A. C., Huynh , H. U. B., Jørgensen, S. H., Mansha , I., Kesmeh , M., Schürch, P. M., Theocharides, A. P. A., Hansen, Paul Robert, Friis , T., Holmeren , M. Ö., Ciplys , E., Slibinskas , R., Højrup, P., Houen, G. & Trier, N. H., 2022, I: International Journal of Molecular Sciences. 23, 12, 21 s., 6803.

      Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

    82. Udgivet

      Reactivity of Rheumatoid Arthritis-Associated Citrulline-Dependent Antibodies to Epstein-Barr Virus Nuclear Antigen1-3

      Fanelli, I., Rovero, P., Hansen, Paul Robert, Frederiksen, J. L., Houen, G. & Trier, N. H., 2022, I: Antibodies. 11, 1, 15 s., 20.

      Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

    83. Udgivet

      Dual high-resolution α-glucosidase and PTP1B profiling combined with HPLC-PDA-HRMS-SPE-NMR analysis for the identification of potentially antidiabetic chromene meroterpenoids in Rhododendron capitatum

      Liang, Chao, Kjaerulff, Louise, Hansen, Paul Robert, Kongstad, Kenneth Thermann & Stærk, Dan, 2021, I: Journal of Natural Products. 84, s. 2454-2467

      Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

    84. Udgivet

      Perfluoro-tert-butanol for selective on-resin detritylation: a mild alternative to traditionally used methods

      Wester, A., Hansen, A. M., Hansen, Paul Robert & Franzyk, Henrik, 2021, I: Amino Acids. 53, s. 1455–1466

      Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

    85. Udgivet

      Specificity of anti-citrullinated protein antibodies to citrullinated α-enolase peptides as a function of epitope structure and composition

      Fanelli, I., Rovero, P., Hansen, Paul Robert, Fredriksen, Jette Lautrup, Houen, G. & Trier, N. H., 2021, I: Antibodies. 10, 3, 12 s., 27.

      Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

    86. Udgivet

      Structure elucidation of prenyl- and geranyl substituted coumarins in Gerbera piloselloides by NMR spectroscopy, electronic circular dichroism calculations, and single crystal X-ray crystallography

      Li, T., Ma, X., Fedotov, D., Kjaerulff, Louise, Frydenvang, Karla Andrea, Coriani, S., Hansen, Paul Robert, Kongstad, Kenneth Thermann & Stærk, Dan, 8 apr. 2020, I: Molecules. 25, 25 s., 1706.

      Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

    87. Udgivet

      Halogenation as a tool to tune antimicrobial activity of peptoids

      Molchanova, N., Nielsen, J. E., Sørensen, K. B., Prabhala, B. K., Hansen, Paul Robert, Lund, R., Barron, A. E. & Jenssen, H., 2020, I: Scientific Reports. 10, 10 s., 14805.

      Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

    88. Udgivet

      Synthesis of Peptoids Containing MultipleNhtrp andNtrp Residues: A Comparative Study of Resin, Cleavage Conditions and Submonomer Protection

      Lone, A., Arnous, A., Hansen, Paul Robert, Mojsoska, B. & Jenssen, H., 2020, I: Frontiers in Chemistry. 8, 12 s., 370.

      Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

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