Duc Ninh Nguyen

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Current research focus

I am leading the research group "Cellular and Molecular Pediatrics", at the section for Comparative Pediatrics and Nutrition, Department of Veterinary and Animal Sciences (IVH), SUND, KU. Our research focuses on

1. Impact of perinatal complications (preterm birth, pre-/post-natal infection and inflammation) on immune development in early life.

2. Host, nutritional status and microbe interaction to determine health in early life.

3. Immunometabolic mechanisms in neonatal infectious diseases (neonatal sepsis, necrotizing enterocolitis-NEC) and novel therapeutic approaches.

Our research platforms and tools are based on: 1) preterm pig model of neonatal sepsis and NEC; 2) observational studies in human preterm infant cohorts; 3) multi-omic analyses (transcriptomics, proteomics, gut microbiome); 4) External collaborations with Danish and international hospitals/research centers working with newborn infants, neonatal mice and preterm lambs.

 

For prospective MSc and PhD students, and postdocs

We are continuously looking for MSc students who are interested in biomedical/immunological research using animal models of neonatal diseases and immune cell in vitro models. Further, we constantly seek external grants for potential PhD students and Postdocs with similar research interests. 

Mulige interessekonflikter

The research has received grants from public/independent funding bodies (Novo Nordisk Foundation, Innovation Fond Denmark, Independent Research Fund Denmark), industry (Takeda, Biofiber-Damino, Arla Foods Ingredients, Arla Foods Amba, Danone), and joint research center between industry and public institutions (center of Arla Food for Health).

Udvalgte publikationer

1. Udgivet

   Glucose supply and glycolysis inhibition shape the clinical fate of Staphylococcus epidermidis-infected preterm newborns

   Muk (Mudi), Tik, Brunse, Anders, Henriksen, Nicole Lind, Aasmul-Olsen, Karoline & Nguyen, Duc Ninh, 2022, I: JCI Insight. 7, 11, 18 s., e157234.

   Publikation: Bidrag til tidsskrift › Tidsskriftartikel › fagfællebedømt

2. Udgivet

   Enteral broad-spectrum antibiotics antagonize the effect of fecal microbiota transplantation in preterm pigs

   Brunse, Anders, Offersen, Simone Margaard, Mosegaard, J. J., Deng, Ling, Damborg, Peter Panduro, Nielsen, Dennis Sandris, Sangild, Per Torp, Thymann, Thomas & Nguyen, Duc Ninh, 2021, I: Gut Microbes. 13, 1, s. 1-16 16 s.

   Publikation: Bidrag til tidsskrift › Tidsskriftartikel › fagfællebedømt

3. Udgivet

   Prenatal inflammation suppresses blood Th1 polarization and gene clusters related to cellular energy metabolism in preterm newborns

   Ren, S., Pan, Xiaoyu, Gao, Fei, Sangild, Per Torp & Nguyen, Duc Ninh, 2020, I: FASEB Journal. 34, 2, s. 2896-2911 16 s.

   Publikation: Bidrag til tidsskrift › Tidsskriftartikel › fagfællebedømt

4. Udgivet

   Prenatal Intra-Amniotic Endotoxin Induces Fetal Gut and Lung Immune Responses and Postnatal Systemic Inflammation in Preterm Pigs

   Nguyen, Duc Ninh, Thymann, Thomas, Goericke-Pesch, S. K., Ren, S., Wei, W., Skovgaard, K., Damborg, Peter Panduro, Brunse, Anders, van Gorp, C., Kramer, B. W., Wolfs, T. G. & Sangild, Per Torp, 2018, I: American Journal of Pathology. 188, 11, s. 2629-2643 15 s.

   Publikation: Bidrag til tidsskrift › Tidsskriftartikel › fagfællebedømt