The longitudinal trajectory of emotional cognition in subgroups of recently diagnosed patients with bipolar disorder
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Although cross-sectional studies show heterogeneity in emotional cognition in bipolar disorder (BD), the temporal course within subgroups is unclear. In this prospective, longitudinal study we assessed the trajectories of emotional cognition subgroups within a 16-month follow-up period in recently diagnosed BD patients compared to healthy controls (HC). Recently diagnosed BD patients and HC underwent comprehensive emotional and non-emotional testing at baseline and again at follow-up. We employed hierarchical cluster analysis at baseline to identify homogenous emotional cognition subgroups of patients, and changes across the subgroups of BD and HC were assessed with linear mixed-model analyses. We found two emotional cognition subgroups: subgroup 1 (65%, n = 179), showing heightened negative emotional reactivity in neutral and negative social scenarios and faster recognition of emotional facial expressions than HC (ps<0.001, n = 190), and subgroup 2 (35%, n = 96) showing blunted reactivity in positive social scenarios, impaired emotion regulation, poorer recognition of positive and slower recognition of all facial expressions than HC (ps≤.03). Subgroup 1 exhibited normalization of the initial emotional cognition abnormalities in follow-up. In contrast, subgroup 2 showed a lack of improvement in reactivity positively-valenced emotional information. Patients in subgroup 2 presented more and longer mixed episodes during the follow-up time and were more often prescribed lithium. One third of patients display blunted emotional reactivity, impaired emotion regulation abilities and facial expression recognition difficulties also show persistent impairments and poorer course of illness. This subgroup may indicate a need for earlier and more targeted therapeutic interventions.
| Originalsprog | Engelsk |
|---|---|
| Tidsskrift | European Neuropsychopharmacology |
| Vol/bind | 71 |
| Sider (fra-til) | 9-24 |
| Antal sider | 16 |
| ISSN | 0924-977X |
| DOI | |
| Status | Udgivet - 2023 |
Bibliografisk note
Funding Information:
The BIO study is funded by grants from the Mental Health Services, Capital Region of Denmark, The Danish Council for Independent Research, Medical Sciences (DFF-4183-00570), Weimans Fund, Markedsmodningsfonden (the Market Development Fund 2015-310), Gangstedfonden (A29594), Helsefonden (16-B-0063), Innovation Fund Denmark (the Innovation Fund, Denmark, 5164-00001B), Copenhagen Center for Health Technology (CACHET), EU H2020 ITN (EU project 722561), Augustinusfonden (16-0083), and The Capital Region of Denmark (A6924). The Research Fund of the Mental Health Services – Capital Region of Denmark has provided HLK's post-doctorate salary. KWM holds an European Research Council (ERC) Consolidator Grant (grant no. 101043416). LSR was supported by Scholarship 88887.475730/2020-00 during the preparation of this manuscript. CAPES Scholarship had no role in writing the manuscript or the decision to submit it for publication.
Funding Information:
The Research Fund of the Mental Health Services – Capital Region of Denmark has provided HLK's post-doctorate salary. KWM holds a five-year Lundbeck Foundation Fellowship (grant no. R215-2015-4121).
Funding Information:
The BIO study is funded by grants from the Mental Health Services, Capital Region of Denmark, The Danish Council for Independent Research, Medical Sciences ( DFF-4183-00570 ), Weimans Fund, Markedsmodningsfonden (the Market Development Fund 2015-310 ), Gangstedfonden ( A29594 ), Helsefonden ( 16-B-0063 ), Innovation Fund Denmark (the Innovation Fund, Denmark, 5164-00001B ), Copenhagen Center for Health Technology (CACHET) , EU H2020 ITN (EU project 722561), Augustinusfonden ( 16-0083 ), and The Capital Region of Denmark ( A6924 ). The Research Fund of the Mental Health Services – Capital Region of Denmark has provided HLK's post-doctorate salary. KWM holds an European Research Council (ERC) Consolidator Grant (grant no. 101043416 ). LSR was supported by Scholarship 88887.475730/2020-00 during the preparation of this manuscript. CAPES Scholarship had no role in writing the manuscript or the decision to submit it for publication.
Publisher Copyright:
© 2023 The Author(s)
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