The longitudinal trajectory of emotional cognition in subgroups of recently diagnosed patients with bipolar disorder

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The longitudinal trajectory of emotional cognition in subgroups of recently diagnosed patients with bipolar disorder. / de Siqueira Rotenberg, Luisa; Kjærstad, Hanne Lie; Varo, Cristina; Vinberg, Maj; Kessing, Lars Vedel; Lafer, Beny; Miskowiak, Kamilla Woznica.

I: European Neuropsychopharmacology, Bind 71, 2023, s. 9-24.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

de Siqueira Rotenberg, L, Kjærstad, HL, Varo, C, Vinberg, M, Kessing, LV, Lafer, B & Miskowiak, KW 2023, 'The longitudinal trajectory of emotional cognition in subgroups of recently diagnosed patients with bipolar disorder', European Neuropsychopharmacology, bind 71, s. 9-24. https://doi.org/10.1016/j.euroneuro.2023.03.005

APA

de Siqueira Rotenberg, L., Kjærstad, H. L., Varo, C., Vinberg, M., Kessing, L. V., Lafer, B., & Miskowiak, K. W. (2023). The longitudinal trajectory of emotional cognition in subgroups of recently diagnosed patients with bipolar disorder. European Neuropsychopharmacology, 71, 9-24. https://doi.org/10.1016/j.euroneuro.2023.03.005

Vancouver

de Siqueira Rotenberg L, Kjærstad HL, Varo C, Vinberg M, Kessing LV, Lafer B o.a. The longitudinal trajectory of emotional cognition in subgroups of recently diagnosed patients with bipolar disorder. European Neuropsychopharmacology. 2023;71:9-24. https://doi.org/10.1016/j.euroneuro.2023.03.005

Author

de Siqueira Rotenberg, Luisa ; Kjærstad, Hanne Lie ; Varo, Cristina ; Vinberg, Maj ; Kessing, Lars Vedel ; Lafer, Beny ; Miskowiak, Kamilla Woznica. / The longitudinal trajectory of emotional cognition in subgroups of recently diagnosed patients with bipolar disorder. I: European Neuropsychopharmacology. 2023 ; Bind 71. s. 9-24.

Bibtex

@article{ee111fca3052488c9c9fef4fec1be39e,

title = "The longitudinal trajectory of emotional cognition in subgroups of recently diagnosed patients with bipolar disorder",

abstract = "Although cross-sectional studies show heterogeneity in emotional cognition in bipolar disorder (BD), the temporal course within subgroups is unclear. In this prospective, longitudinal study we assessed the trajectories of emotional cognition subgroups within a 16-month follow-up period in recently diagnosed BD patients compared to healthy controls (HC). Recently diagnosed BD patients and HC underwent comprehensive emotional and non-emotional testing at baseline and again at follow-up. We employed hierarchical cluster analysis at baseline to identify homogenous emotional cognition subgroups of patients, and changes across the subgroups of BD and HC were assessed with linear mixed-model analyses. We found two emotional cognition subgroups: subgroup 1 (65%, n = 179), showing heightened negative emotional reactivity in neutral and negative social scenarios and faster recognition of emotional facial expressions than HC (ps<0.001, n = 190), and subgroup 2 (35%, n = 96) showing blunted reactivity in positive social scenarios, impaired emotion regulation, poorer recognition of positive and slower recognition of all facial expressions than HC (ps≤.03). Subgroup 1 exhibited normalization of the initial emotional cognition abnormalities in follow-up. In contrast, subgroup 2 showed a lack of improvement in reactivity positively-valenced emotional information. Patients in subgroup 2 presented more and longer mixed episodes during the follow-up time and were more often prescribed lithium. One third of patients display blunted emotional reactivity, impaired emotion regulation abilities and facial expression recognition difficulties also show persistent impairments and poorer course of illness. This subgroup may indicate a need for earlier and more targeted therapeutic interventions.",

keywords = "Bipolar disorder, Cluster analysis, Emotion regulation, Emotional cognition, Longitudinal",

author = "{de Siqueira Rotenberg}, Luisa and Kj{\ae}rstad, {Hanne Lie} and Cristina Varo and Maj Vinberg and Kessing, {Lars Vedel} and Beny Lafer and Miskowiak, {Kamilla Woznica}",

note = "Publisher Copyright: {\textcopyright} 2023 The Author(s)",

year = "2023",

doi = "10.1016/j.euroneuro.2023.03.005",

language = "English",

volume = "71",

pages = "9--24",

journal = "European Neuropsychopharmacology",

issn = "0924-977X",

publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - The longitudinal trajectory of emotional cognition in subgroups of recently diagnosed patients with bipolar disorder

AU - de Siqueira Rotenberg, Luisa

AU - Kjærstad, Hanne Lie

AU - Varo, Cristina

AU - Vinberg, Maj

AU - Kessing, Lars Vedel

AU - Lafer, Beny

AU - Miskowiak, Kamilla Woznica

PY - 2023

Y1 - 2023

N2 - Although cross-sectional studies show heterogeneity in emotional cognition in bipolar disorder (BD), the temporal course within subgroups is unclear. In this prospective, longitudinal study we assessed the trajectories of emotional cognition subgroups within a 16-month follow-up period in recently diagnosed BD patients compared to healthy controls (HC). Recently diagnosed BD patients and HC underwent comprehensive emotional and non-emotional testing at baseline and again at follow-up. We employed hierarchical cluster analysis at baseline to identify homogenous emotional cognition subgroups of patients, and changes across the subgroups of BD and HC were assessed with linear mixed-model analyses. We found two emotional cognition subgroups: subgroup 1 (65%, n = 179), showing heightened negative emotional reactivity in neutral and negative social scenarios and faster recognition of emotional facial expressions than HC (ps<0.001, n = 190), and subgroup 2 (35%, n = 96) showing blunted reactivity in positive social scenarios, impaired emotion regulation, poorer recognition of positive and slower recognition of all facial expressions than HC (ps≤.03). Subgroup 1 exhibited normalization of the initial emotional cognition abnormalities in follow-up. In contrast, subgroup 2 showed a lack of improvement in reactivity positively-valenced emotional information. Patients in subgroup 2 presented more and longer mixed episodes during the follow-up time and were more often prescribed lithium. One third of patients display blunted emotional reactivity, impaired emotion regulation abilities and facial expression recognition difficulties also show persistent impairments and poorer course of illness. This subgroup may indicate a need for earlier and more targeted therapeutic interventions.

AB - Although cross-sectional studies show heterogeneity in emotional cognition in bipolar disorder (BD), the temporal course within subgroups is unclear. In this prospective, longitudinal study we assessed the trajectories of emotional cognition subgroups within a 16-month follow-up period in recently diagnosed BD patients compared to healthy controls (HC). Recently diagnosed BD patients and HC underwent comprehensive emotional and non-emotional testing at baseline and again at follow-up. We employed hierarchical cluster analysis at baseline to identify homogenous emotional cognition subgroups of patients, and changes across the subgroups of BD and HC were assessed with linear mixed-model analyses. We found two emotional cognition subgroups: subgroup 1 (65%, n = 179), showing heightened negative emotional reactivity in neutral and negative social scenarios and faster recognition of emotional facial expressions than HC (ps<0.001, n = 190), and subgroup 2 (35%, n = 96) showing blunted reactivity in positive social scenarios, impaired emotion regulation, poorer recognition of positive and slower recognition of all facial expressions than HC (ps≤.03). Subgroup 1 exhibited normalization of the initial emotional cognition abnormalities in follow-up. In contrast, subgroup 2 showed a lack of improvement in reactivity positively-valenced emotional information. Patients in subgroup 2 presented more and longer mixed episodes during the follow-up time and were more often prescribed lithium. One third of patients display blunted emotional reactivity, impaired emotion regulation abilities and facial expression recognition difficulties also show persistent impairments and poorer course of illness. This subgroup may indicate a need for earlier and more targeted therapeutic interventions.

KW - Bipolar disorder

KW - Cluster analysis

KW - Emotion regulation

KW - Emotional cognition

KW - Longitudinal

U2 - 10.1016/j.euroneuro.2023.03.005

DO - 10.1016/j.euroneuro.2023.03.005

M3 - Journal article

C2 - 36965236

AN - SCOPUS:85151003887

VL - 71

SP - 9

EP - 24

JO - European Neuropsychopharmacology

JF - European Neuropsychopharmacology

SN - 0924-977X

ER -

ID: 341348865