Coating of bone implants with silica, hyperbranched polyethyleneimine, and gentamicin prevents development of osteomyelitis in a porcine model

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  • Mats Bue
  • Pelle Hanberg
  • Yuly López
  • Sara M. Soto
  • Marilina Douloudi
  • Michaela Papageorgiou
  • Eleni Nikoli
  • Michael Arkas
  • Ignacio Gutiérrez-del-Río
  • Sara López-Ibáñez
  • Claudio J. Villar
  • Felipe Lombó
  • Paraskevi Gkomoza
  • Ioanna Kitsou
  • Athina Tsetsekou
  • Michalis Vardavoulias

The use of bone implants and prostheses has contributed to a revolution in modern medicine; however, in the beginning, not much was asked from the implant and prosthetic materials per se. Therefore, the next game-changer in orthopedic research will come from new material designs which for instance can aid in prevention of implant-associated bone infections. Here, we describe the development of a new sol-gel coating technique that can deliver an efficient antimicrobial surface coating on orthopedic implants. Gentamicin was stocked in a novel nanocomposite xerogel made from silica and hyperbranched polyethyleneimine. The xerogel was anchored inside a porous surface made by coating of bone implants with titanium microspheres. Thereby, only the small water-soluble gentamicin molecules diffused in an aqueous environment, i.e., just after surgical insertion and leaving behind a titanium scaffold for osseointegration. The novel xerogel coating prevented development of severe Staphylococcus aureus induced osteomyelitis in a porcine model, which untreated, replicated the pathology seen in stage 3A on the Cierny–Mader classification system for osteomyelitis in adults.

StatusUdgivet - 2022

Bibliografisk note

Funding Information:
We would like to thank Betina Andersen and Elizabeth Petersen for excellent laboratory assistance with histology and immunohistochemistry. This study was financed by the European Union's Horizon 2020 research and innovation program under NOMORFILM project grant agreement No 634588 and grant no. R-345-2020-1674 from the Lundbeck Foundation to LKJ. All financial aspects have been covered by the two grants.

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© 2022 The Authors

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