Coating of bone implants with silica, hyperbranched polyethyleneimine, and gentamicin prevents development of osteomyelitis in a porcine model

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Standard

Coating of bone implants with silica, hyperbranched polyethyleneimine, and gentamicin prevents development of osteomyelitis in a porcine model. / Jensen, Louise Kruse; Jensen, Henrik Elvang; Blirup-Plum, Sophie Amalie; Bue, Mats; Hanberg, Pelle; Kvich, Lasse; Aalbæk, Bent; López, Yuly; Soto, Sara M.; Douloudi, Marilina; Papageorgiou, Michaela; Nikoli, Eleni; Arkas, Michael; Gutiérrez-del-Río, Ignacio; López-Ibáñez, Sara; Villar, Claudio J.; Lombó, Felipe; Gkomoza, Paraskevi; Kitsou, Ioanna; Tsetsekou, Athina; Vardavoulias, Michalis.

I: Materialia, Bind 24, 101473, 2022.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Jensen, LK, Jensen, HE, Blirup-Plum, SA, Bue, M, Hanberg, P, Kvich, L, Aalbæk, B, López, Y, Soto, SM, Douloudi, M, Papageorgiou, M, Nikoli, E, Arkas, M, Gutiérrez-del-Río, I, López-Ibáñez, S, Villar, CJ, Lombó, F, Gkomoza, P, Kitsou, I, Tsetsekou, A & Vardavoulias, M 2022, 'Coating of bone implants with silica, hyperbranched polyethyleneimine, and gentamicin prevents development of osteomyelitis in a porcine model', Materialia, bind 24, 101473. https://doi.org/10.1016/j.mtla.2022.101473

APA

Jensen, L. K., Jensen, H. E., Blirup-Plum, S. A., Bue, M., Hanberg, P., Kvich, L., Aalbæk, B., López, Y., Soto, S. M., Douloudi, M., Papageorgiou, M., Nikoli, E., Arkas, M., Gutiérrez-del-Río, I., López-Ibáñez, S., Villar, C. J., Lombó, F., Gkomoza, P., Kitsou, I., ... Vardavoulias, M. (2022). Coating of bone implants with silica, hyperbranched polyethyleneimine, and gentamicin prevents development of osteomyelitis in a porcine model. Materialia, 24, [101473]. https://doi.org/10.1016/j.mtla.2022.101473

Vancouver

Jensen LK, Jensen HE, Blirup-Plum SA, Bue M, Hanberg P, Kvich L o.a. Coating of bone implants with silica, hyperbranched polyethyleneimine, and gentamicin prevents development of osteomyelitis in a porcine model. Materialia. 2022;24. 101473. https://doi.org/10.1016/j.mtla.2022.101473

Author

Jensen, Louise Kruse ; Jensen, Henrik Elvang ; Blirup-Plum, Sophie Amalie ; Bue, Mats ; Hanberg, Pelle ; Kvich, Lasse ; Aalbæk, Bent ; López, Yuly ; Soto, Sara M. ; Douloudi, Marilina ; Papageorgiou, Michaela ; Nikoli, Eleni ; Arkas, Michael ; Gutiérrez-del-Río, Ignacio ; López-Ibáñez, Sara ; Villar, Claudio J. ; Lombó, Felipe ; Gkomoza, Paraskevi ; Kitsou, Ioanna ; Tsetsekou, Athina ; Vardavoulias, Michalis. / Coating of bone implants with silica, hyperbranched polyethyleneimine, and gentamicin prevents development of osteomyelitis in a porcine model. I: Materialia. 2022 ; Bind 24.

Bibtex

@article{7a4b22f30c2c4e13822187a8d136755c,

title = "Coating of bone implants with silica, hyperbranched polyethyleneimine, and gentamicin prevents development of osteomyelitis in a porcine model",

abstract = "The use of bone implants and prostheses has contributed to a revolution in modern medicine; however, in the beginning, not much was asked from the implant and prosthetic materials per se. Therefore, the next game-changer in orthopedic research will come from new material designs which for instance can aid in prevention of implant-associated bone infections. Here, we describe the development of a new sol-gel coating technique that can deliver an efficient antimicrobial surface coating on orthopedic implants. Gentamicin was stocked in a novel nanocomposite xerogel made from silica and hyperbranched polyethyleneimine. The xerogel was anchored inside a porous surface made by coating of bone implants with titanium microspheres. Thereby, only the small water-soluble gentamicin molecules diffused in an aqueous environment, i.e., just after surgical insertion and leaving behind a titanium scaffold for osseointegration. The novel xerogel coating prevented development of severe Staphylococcus aureus induced osteomyelitis in a porcine model, which untreated, replicated the pathology seen in stage 3A on the Cierny–Mader classification system for osteomyelitis in adults.",

keywords = "Antibacterial coating, Bone implants, Osteomyelitis, Porcine model",

author = "Jensen, {Louise Kruse} and Jensen, {Henrik Elvang} and Blirup-Plum, {Sophie Amalie} and Mats Bue and Pelle Hanberg and Lasse Kvich and Bent Aalb{\ae}k and Yuly L{\'o}pez and Soto, {Sara M.} and Marilina Douloudi and Michaela Papageorgiou and Eleni Nikoli and Michael Arkas and Ignacio Guti{\'e}rrez-del-R{\'i}o and Sara L{\'o}pez-Ib{\'a}{\~n}ez and Villar, {Claudio J.} and Felipe Lomb{\'o} and Paraskevi Gkomoza and Ioanna Kitsou and Athina Tsetsekou and Michalis Vardavoulias",

note = "Publisher Copyright: {\textcopyright} 2022 The Authors",

year = "2022",

doi = "10.1016/j.mtla.2022.101473",

language = "English",

volume = "24",

journal = "Materialia",

issn = "2589-1529",

publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Coating of bone implants with silica, hyperbranched polyethyleneimine, and gentamicin prevents development of osteomyelitis in a porcine model

AU - Jensen, Louise Kruse

AU - Jensen, Henrik Elvang

AU - Blirup-Plum, Sophie Amalie

AU - Bue, Mats

AU - Hanberg, Pelle

AU - Kvich, Lasse

AU - Aalbæk, Bent

AU - López, Yuly

AU - Soto, Sara M.

AU - Douloudi, Marilina

AU - Papageorgiou, Michaela

AU - Nikoli, Eleni

AU - Arkas, Michael

AU - Gutiérrez-del-Río, Ignacio

AU - López-Ibáñez, Sara

AU - Villar, Claudio J.

AU - Lombó, Felipe

AU - Gkomoza, Paraskevi

AU - Kitsou, Ioanna

AU - Tsetsekou, Athina

AU - Vardavoulias, Michalis

PY - 2022

Y1 - 2022

N2 - The use of bone implants and prostheses has contributed to a revolution in modern medicine; however, in the beginning, not much was asked from the implant and prosthetic materials per se. Therefore, the next game-changer in orthopedic research will come from new material designs which for instance can aid in prevention of implant-associated bone infections. Here, we describe the development of a new sol-gel coating technique that can deliver an efficient antimicrobial surface coating on orthopedic implants. Gentamicin was stocked in a novel nanocomposite xerogel made from silica and hyperbranched polyethyleneimine. The xerogel was anchored inside a porous surface made by coating of bone implants with titanium microspheres. Thereby, only the small water-soluble gentamicin molecules diffused in an aqueous environment, i.e., just after surgical insertion and leaving behind a titanium scaffold for osseointegration. The novel xerogel coating prevented development of severe Staphylococcus aureus induced osteomyelitis in a porcine model, which untreated, replicated the pathology seen in stage 3A on the Cierny–Mader classification system for osteomyelitis in adults.

AB - The use of bone implants and prostheses has contributed to a revolution in modern medicine; however, in the beginning, not much was asked from the implant and prosthetic materials per se. Therefore, the next game-changer in orthopedic research will come from new material designs which for instance can aid in prevention of implant-associated bone infections. Here, we describe the development of a new sol-gel coating technique that can deliver an efficient antimicrobial surface coating on orthopedic implants. Gentamicin was stocked in a novel nanocomposite xerogel made from silica and hyperbranched polyethyleneimine. The xerogel was anchored inside a porous surface made by coating of bone implants with titanium microspheres. Thereby, only the small water-soluble gentamicin molecules diffused in an aqueous environment, i.e., just after surgical insertion and leaving behind a titanium scaffold for osseointegration. The novel xerogel coating prevented development of severe Staphylococcus aureus induced osteomyelitis in a porcine model, which untreated, replicated the pathology seen in stage 3A on the Cierny–Mader classification system for osteomyelitis in adults.

KW - Antibacterial coating

KW - Bone implants

KW - Osteomyelitis

KW - Porcine model

U2 - 10.1016/j.mtla.2022.101473

DO - 10.1016/j.mtla.2022.101473

M3 - Journal article

AN - SCOPUS:85132387588

VL - 24

JO - Materialia

JF - Materialia

SN - 2589-1529

M1 - 101473

ER -

ID: 313494866