Chelating chloride using binuclear lanthanide complexes in water
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Halide recognition by supramolecular receptors and coordination complexes in water is a long-standing challenge. In this work, we report chloride binding in water and in competing media by pre-organised binuclear kinetically inert lanthanide complexes, bridged by flexible -(CH2)2- and -(CH2)3- spacers, forming [Ln2(DO3A)2C-2] and [Ln2(DO3A)2C-3], respectively. These hydrophilic, neutral lanthanide coordination complexes are shown to bind chloride with apparent association constants of up to 105 M−1 in water and in buffered systems. Hydroxide bridging was observed in these complexes at basic pH, which was proven to be overcome by chloride. Thus, these lanthanide complexes show promise towards chloride recognition in biology and beyond. The results described here have clearly identified a new area of anion coordination chemistry that is ripe for detailed exploration.
Originalsprog | Engelsk |
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Tidsskrift | Chemical Science |
Vol/bind | 14 |
Udgave nummer | 5 |
Sider (fra-til) | 1194-1204 |
Antal sider | 11 |
ISSN | 2041-6520 |
DOI | |
Status | Udgivet - 2023 |
Bibliografisk note
Funding Information:
The authors thank the University of Oxford for support. C. A. acknowledges the RSC Researcher Mobility Grant (grant no. MI9-0393) for partial financial support towards this project and Research England GCRF QR fund for providing partial scholarship. C. A. thanks Dr Leila Hill for advice on using DYNAFIT® and thermodynamic study Dr Nicholas H. Rees for helpful advice and support on Cl NMR, Faulkner group members (Dr Grace McMullon, Dr Daniel Kovacs, Cameron Gray, Dr Deborah Sneddon, and Clara von Randow), and Zongyao Zhang for suggestions incorporated in this work. , 35
Publisher Copyright:
© 2023 The Royal Society of Chemistry.
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