Chuna Ram Choudhary

Chuna Ram Choudhary

Professor, gruppeleder, Professor

Medlem af:

    Dr. Chuna Ram Choudhary is currently a professor and group leader at the Novo Nordisk Foundation Center for Protein Research at the University of Copenhagen in Denmark. He carried out his doctoral studies at the University of Münster in Germany (under Prof. Dr. Hubert Serve) and his postdoctoral training at the same university as well as at the Max Planck Institute for Biochemistry in Martinsried, Germany (under Prof. Dr. Matthias Mann). Dr. Choudhary has been widely published in many reputable, peer-reviewed journals and in 2012, was awarded a prestigious Sapere Aude research grant from the Danish Research Council. His laboratory is interested in investigating the dynamics of protein posttranslational modifications, in particular of lysine acetylation and ubiquitylation, in cell signaling networks using quantitative mass spectrometry-based approaches.

    Primære forskningsområder

    Biological systems respond to a wide range of extracellular and intracellular cues (signals), resulting in a myriad of diverse outcomes. Cells respond to these signals by modulating expression levels of protein as well as by regulating their functions via posttranslational modifications (PTMs). PTMs have critical roles in the dynamic regulation of protein activity, stability, spatial localization, and communication with other macromolecules within cells. Deregulation of PTM modifying enzymes, such as protein kinases, ubiquitin ligases, and lysine deacetylases, is often observed in human diseases further highlighting the importance of their regulatory functions. Thus, unraveling the scope of PTMs, their link to regulatory enzymes, and their dynamics in response to cellular perturbations is critically important for obtaining a better understanding of the principles of cellular governance.

    A major focus of the Group is to obtain a 'systems-wide' understanding of signaling networks. For this, our laboratory applies cutting-edge mass spectrometry-based proteomics technologies for unbiased, global, and quantitative analysis of key regulatory PTMs. We work closely with other groups within the Centre as well as with our national and international collaborators.

    Udvalgte publikationer

    1. Udgivet

      Functions and mechanisms of non-histone protein acetylation

      Narita, Takeo, Weinert, B. T. & Choudhary, Chunaram, 2019, I: Nature Reviews. Molecular Cell Biology. 20, s. 156-174 19 s.

      Publikation: Bidrag til tidsskriftReviewForskningfagfællebedømt

    2. Udgivet

      Analysis and Interpretation of Protein Post-Translational Modification Site Stoichiometry

      Prus, Gabriela Zofia, Hoegl, A., Weinert, B. T. & Choudhary, Chunaram, 2019, I: Trends in Biochemical Sciences. 44, 11, s. 943-960

      Publikation: Bidrag til tidsskriftReviewForskningfagfællebedømt

    3. Udgivet

      Time-Resolved Analysis Reveals Rapid Dynamics and Broad Scope of the CBP/p300 Acetylome

      Weinert, B. T., Narita, Takeo, Satpathy, S., Srinivasan, B., Hansen, B. K., Schölz, C., Hamilton, W. B., Zucconi, B. E., Wang, W. W., Liu, W. R., Brickman, Joshua Mark, Kesicki, E. A., Lai, A., Bromberg, K. D., Cole, P. A. & Choudhary, Chunaram, 2018, I: Cell. 174, 1, s. 231-244.e12 27 s.

      Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

    4. Udgivet

      DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity

      Gupta, R., Somyajit, K., Narita, Takeo, Maskey, E., Stanlie, A., Kremer, M., Typas, D., Lammers, M., Mailand, Niels, Nussenzweig, A., Lukas, Jiri & Choudhary, Chunaram, 2018, I: Cell. 173, 4, s. 972-988

      Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

    5. Udgivet

      Acetylation site specificities of lysine deacetylase inhibitors in human cells

      Schölz, C., Weinert, B. T., Wagner, S. A., Beli, P., Miyake, Y., Qi, J., Jensen, Lars Juhl, Streicher, W., McCarthy, A. R., Westwood, N. J., Lain, S., Cox, J., Matthias, P., Mann, M., Bradner, J. E. & Choudhary, Chunaram, 2015, I: Nature Biotechnology. 33, s. 415–423

      Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

    6. Udgivet

      The growing landscape of lysine acetylation links metabolism and cell signalling

      Choudhary, Chunaram, Weinert, B. T., Nishida, Y., Verdin, E. & Mann, Matthias, 23 jul. 2014, I: Nature Reviews. Molecular Cell Biology. 15, 8, s. 536-50 15 s.

      Publikation: Bidrag til tidsskriftReviewForskningfagfællebedømt

    7. Udgivet

      Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli

      Weinert, B. T., Iesmantavicius, V., Wagner, S. A., Schölz, C., Gummesson, Bertil, Beli, P., Nyström, T. & Choudhary, Chunaram, 25 jul. 2013, I: Molecular Cell. 51, 2, s. 265-272 8 s.

      Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

    8. Udgivet

      Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass

      Povlsen, L. K., Beli, P., Wagner, S. A., Poulsen, S. L., Sylvestersen, K. B., Poulsen, J. W., Nielsen, Michael Lund, Bekker-Jensen, Simon Holst, Mailand, Niels & Choudhary, Chunaram, okt. 2012, I: Nature Cell Biology. 14, 10, s. 1089-98 10 s.

      Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

    9. Udgivet

      Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response

      Beli, P., Lukashchuk, N., Wagner, S. A., Weinert, B. T., Olsen, Jesper Velgaard, Baskcomb, L., Mann, Matthias, Jackson, S. P. & Choudhary, Chunaram, 2012, I: Molecular Cell. 46, 2, s. 212-25 14 s.

      Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

    10. Udgivet

      Lysine acetylation targets protein complexes and co-regulates major cellular functions

      Choudhary, Chunaram, Kumar, C., Gnad, F., Nielsen, Michael Lund, Rehman, M., Walther, T. C., Olsen, Jesper Velgaard & Mann, Matthias, 2009, I: Science. 325, 5942, s. 834-40 6 s.

      Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

    ID: 13781159