Jiri Lukas

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Primære forskningsområder

Jiri Lukas studies protein pathways that orchestrate spatial and temporal dynamics of chromosomes during the mammalian cell cycle and after DNA damage, with an emphasis on how are these mechanisms subverted in cancer and other diseases associated with unstable genomes. His long-term interests include high-content microscopy screens for genome caretakers and real-time imaging of signaling and repair proteins.

Aktuel forskning

Recent discoveries from Jiri’s lab include:

• Ubiquitin-driven signalling pathways that barcode chromatin near the DNA lesions to assemble repair and signaling proteins
• Heritability of chromosomal lesions generated on unreplicated DNA during mitosis
• The concept of rate imitation of nodal signaling components as a mechanism to confine repair reactions and posttranslational chromatin modifications to damaged loci in the genome

Udvalgte publikationer

1. Udgivet

   Stabilization of chromatin topology safeguards genome integrity

   Ochs, Fena, Karemore, Gopal, Miron, E., Brown, J., Sedlackova, H., Rask, M., Lampe, M., Buckle, V., Schermelleh, L., Lukas, Jiri & Lukas, Claudia, 2019, I: Nature. 574, 7779, s. 571-574 4 s.

   Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

2. Udgivet

   Replication Catastrophe: When a Checkpoint Fails because of Exhaustion

   Toledo, L., Neelsen, K. J. & Lukas, Jiri, 15 jun. 2017, I: Molecular Cell. 66, 6, s. 735-749 15 s.

   Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt

3. Udgivet

   Redox-sensitive alteration of replisome architecture safeguards genome integrity

   Somyajit, K., Gupta, R., Sedlackova, H., Neelsen, K. J., Ochs, Fena, Rask, M., Choudhary, Chunaram & Lukas, Jiri, 10 nov. 2017, I: Science. 358, 6364, s. 797-802 6 s.

   Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

4. Udgivet

   ATR Prohibits Replication Catastrophe by Preventing Global Exhaustion of RPA

   Toledo Lazaro, L. I., Altmeyer, M., Rask, M., Lukas, Claudia, Larsen, D. H., Povlsen, L. K., Bekker-Jensen, Simon Holst, Mailand, Niels, Bartek, J. & Lukas, Jiri, 21 nov. 2013, I: Cell. 155, 5, s. 1088-1103 16 s.

   Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

5. Udgivet

   TRIP12 and UBR5 Suppress Spreading of Chromatin Ubiquitylation at Damaged Chromosomes

   Gudjónsson, Thorkell, Altmeyer, M. F., Savic, V., Toledo Lazaro, L. I., Dinant, C., Grøfte, M., Bartkova, J., Poulsen, M., Oka, Y., Bekker-Jensen, Simon Holst, Mailand, Niels, Neumann, B., Heriche, J., Shearer, R., Saunders, D., Bartek, J., Lukas, Jiri & Lukas, Claudia, 17 aug. 2012, I: Cell. 150, 4, s. 697-709 13 s.

   Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

6. Udgivet

   53BP1 nuclear bodies form around DNA lesions generated by mitotic transmission of chromosomes under replication stress

   Lukas, Claudia, Savic, V., Bekker-Jensen, Simon Holst, Doil, C., Neumann, B., Pedersen, R. S., Grøfte, M., Chan, K. L., Hickson, Ian David, Bartek, J. & Lukas, Jiri, 1 mar. 2011, I: Nature Cell Biology. 13, 3, s. 243-53 11 s.

   Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

7. RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins

   Doil, C., Mailand, Niels, Bekker-Jensen, Simon Holst, Ménard, Patrice, Larsen, D. H., Pepperkok, R., Ellenberg, J., Panier, S., Durocher, D., Bartek, J., Lukas, Jiri & Lukas, Claudia, 2009, I: Cell. 136, 3, s. 435-46 11 s.

   Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt