Vitamin D3 Supplementation in Overweight/Obese Pregnant Women: No Effects on the Maternal or Fetal Lipid Profile and Body Fat Distribution—A Secondary Analysis of the Multicentric, Randomized, Controlled Vitamin D and Lifestyle for Gestational Diabetes Prevention Trial (DALI)
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Vitamin D deficiency is a common finding in overweight/obese pregnant women and is associated with increased risk for adverse pregnancy outcome. Both maternal vitamin D deficiency and maternal obesity contribute to metabolic derangements in pregnancy. We aimed to assess the effects of vitamin D3 supplementation in pregnancy versus placebo on maternal and fetal lipids. Main inclusion criteria were: women <20 weeks’ gestation, BMI ≥ 29 kg/m2. Eligible women (n = 154) were randomized to receive vitamin D3 (1600 IU/day) or placebo. Assessments were performed <20, 24–28 and 35–37 weeks and at birth. Linear regression models were used to assess effects of vitamin D on maternal and cord blood lipids. In the vitamin D group significantly higher total 25-OHD and 25-OHD3 levels were found in maternal and cord blood compared with placebo. Adjusted regression models did not reveal any differences in triglycerides, LDL-C, HDL-C, free fatty acids, ketone bodies or leptin between groups. Neonatal sum of skinfolds was comparable between the two groups, but correlated positively with cord blood 25-OH-D3 (r = 0.34, p = 0.012). Vitamin D supplementation in pregnancy increases maternal and cord blood vitamin D significantly resulting in high rates of vitamin D sufficiency. Maternal and cord blood lipid parameters were unaffected by Vitamin D3 supplementation.
| Originalsprog | Engelsk |
|---|---|
| Artikelnummer | 3781 |
| Tidsskrift | Nutrients |
| Vol/bind | 14 |
| Udgave nummer | 18 |
| ISSN | 2072-6643 |
| DOI | |
| Status | Udgivet - 2022 |
Bibliografisk note
Funding Information:
The vitamin D And LIfestyle for gestational diabetes prevention trial (DALI) was a prospective European-wide multicentre randomized controlled trial (RCT) designed to investigate the potential preventive effects of different lifestyle approaches or vitamin D3 supplementation on GDM progression in obese pregnant women recruited prior to 20 weeks gestation, as previously reported elsewhere [,,,]. The Vitamin D intervention trial included women (n = 154) from 7 European countries (United Kingdom, Ireland, Austria, Poland, Italy (2 centres), Spain and Belgium) aged ≥ 18 years, singleton pregnancy before 20 weeks of gestation, pre-pregnancy BMI ≥ 29 kg/m, and ability to give informed consent. Exclusion criteria included pre-existing diabetes, need for complex diets, inability to walk ≥ 100 m safely, significant chronic medical conditions, current or past abnormal calcium metabolism (hypo/hyperparathyroidism, nephrolithiasis, hypercalciuria or hypercalcemia). Recruitment was conducted between 2012 and 2015. The DALI trial was approved by each local research ethics committee. Written informed consent was obtained from all participating subjects. DALI was registered in ISRCTN registry (ISRCTN70595832) and funded by the European Union 7th framework program (Grant Agreement no. 242187). 2
Funding Information:
DALI has received funding from the European Community’s 7th Framework Programme (FP7/2007–2013) under grant agreement no. 242187. In the Netherlands, additional funding was provided by the Netherlands Organization for Health Research and Development (ZonMw) (grant no. 200310013). In Poland, additional funding was obtained from Polish Ministry of Science (grant no. 2203/7. PR/2011/2). In Denmark, additional funding was provided by the Odense University Free Research Fund. In the United Kingdom, the local DALI team was supported by NIHR Clinical Research Network: Eastern. In Spain, additional funding was provided by CAIBER 1527-B-226. The funders had no role in any aspect of the study beyond funding.
Publisher Copyright:
© 2022 by the authors.
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