Vitamin D3 Supplementation in Overweight/Obese Pregnant Women: No Effects on the Maternal or Fetal Lipid Profile and Body Fat Distribution—A Secondary Analysis of the Multicentric, Randomized, Controlled Vitamin D and Lifestyle for Gestational Diabetes Prevention Trial (DALI)

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Standard

Vitamin D3 Supplementation in Overweight/Obese Pregnant Women : No Effects on the Maternal or Fetal Lipid Profile and Body Fat Distribution—A Secondary Analysis of the Multicentric, Randomized, Controlled Vitamin D and Lifestyle for Gestational Diabetes Prevention Trial (DALI). / Harreiter, Jürgen; on behalf of the DALI Core Investigator Group.

I: Nutrients, Bind 14, Nr. 18, 3781, 2022.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Harreiter, J & on behalf of the DALI Core Investigator Group 2022, 'Vitamin D3 Supplementation in Overweight/Obese Pregnant Women: No Effects on the Maternal or Fetal Lipid Profile and Body Fat Distribution—A Secondary Analysis of the Multicentric, Randomized, Controlled Vitamin D and Lifestyle for Gestational Diabetes Prevention Trial (DALI)', Nutrients, bind 14, nr. 18, 3781. https://doi.org/10.3390/nu14183781

APA

Harreiter, J., & on behalf of the DALI Core Investigator Group (2022). Vitamin D3 Supplementation in Overweight/Obese Pregnant Women: No Effects on the Maternal or Fetal Lipid Profile and Body Fat Distribution—A Secondary Analysis of the Multicentric, Randomized, Controlled Vitamin D and Lifestyle for Gestational Diabetes Prevention Trial (DALI). Nutrients, 14(18), [3781]. https://doi.org/10.3390/nu14183781

Vancouver

Harreiter J, on behalf of the DALI Core Investigator Group. Vitamin D3 Supplementation in Overweight/Obese Pregnant Women: No Effects on the Maternal or Fetal Lipid Profile and Body Fat Distribution—A Secondary Analysis of the Multicentric, Randomized, Controlled Vitamin D and Lifestyle for Gestational Diabetes Prevention Trial (DALI). Nutrients. 2022;14(18). 3781. https://doi.org/10.3390/nu14183781

Author

Harreiter, Jürgen ; on behalf of the DALI Core Investigator Group. / Vitamin D3 Supplementation in Overweight/Obese Pregnant Women : No Effects on the Maternal or Fetal Lipid Profile and Body Fat Distribution—A Secondary Analysis of the Multicentric, Randomized, Controlled Vitamin D and Lifestyle for Gestational Diabetes Prevention Trial (DALI). I: Nutrients. 2022 ; Bind 14, Nr. 18.

Bibtex

@article{e0eb32accdad4472b78cda851fb34b80,
title = "Vitamin D3 Supplementation in Overweight/Obese Pregnant Women: No Effects on the Maternal or Fetal Lipid Profile and Body Fat Distribution—A Secondary Analysis of the Multicentric, Randomized, Controlled Vitamin D and Lifestyle for Gestational Diabetes Prevention Trial (DALI)",
abstract = "Vitamin D deficiency is a common finding in overweight/obese pregnant women and is associated with increased risk for adverse pregnancy outcome. Both maternal vitamin D deficiency and maternal obesity contribute to metabolic derangements in pregnancy. We aimed to assess the effects of vitamin D3 supplementation in pregnancy versus placebo on maternal and fetal lipids. Main inclusion criteria were: women <20 weeks{\textquoteright} gestation, BMI ≥ 29 kg/m2. Eligible women (n = 154) were randomized to receive vitamin D3 (1600 IU/day) or placebo. Assessments were performed <20, 24–28 and 35–37 weeks and at birth. Linear regression models were used to assess effects of vitamin D on maternal and cord blood lipids. In the vitamin D group significantly higher total 25-OHD and 25-OHD3 levels were found in maternal and cord blood compared with placebo. Adjusted regression models did not reveal any differences in triglycerides, LDL-C, HDL-C, free fatty acids, ketone bodies or leptin between groups. Neonatal sum of skinfolds was comparable between the two groups, but correlated positively with cord blood 25-OH-D3 (r = 0.34, p = 0.012). Vitamin D supplementation in pregnancy increases maternal and cord blood vitamin D significantly resulting in high rates of vitamin D sufficiency. Maternal and cord blood lipid parameters were unaffected by Vitamin D3 supplementation.",
keywords = "birth outcomes, body fat distribution, cholesterol, cord blood, free fatty acids, lipids, obesity pregnancy, overweight, pregnancy outcomes, skinfolds, triglycerides, vitamin D",
author = "J{\"u}rgen Harreiter and Mendoza, {Lilian C.} and David Simmons and Gernot Desoye and Roland Devlieger and Sander Galjaard and Peter Damm and Mathiesen, {Elisabeth R.} and Jensen, {Dorte M.} and Andersen, {Lise Lotte T.} and Fidelma Dunne and Annunziata Lapolla and Dalfra, {Maria G.} and Alessandra Bertolotto and Ewa Wender-Ozegowska and Agnieszka Zawiejska and David Hill and Jelsma, {Judith G.M.} and Snoek, {Frank J.} and Christof Worda and Dagmar Bancher-Todesca and {van Poppel}, {Mireille N.M.} and Rosa Corcoy and Alexandra Kautzky-Willer and {on behalf of the DALI Core Investigator Group}",
note = "Publisher Copyright: {\textcopyright} 2022 by the authors.",
year = "2022",
doi = "10.3390/nu14183781",
language = "English",
volume = "14",
journal = "Nutrients",
issn = "2072-6643",
publisher = "M D P I AG",
number = "18",

}

RIS

TY - JOUR

T1 - Vitamin D3 Supplementation in Overweight/Obese Pregnant Women

T2 - No Effects on the Maternal or Fetal Lipid Profile and Body Fat Distribution—A Secondary Analysis of the Multicentric, Randomized, Controlled Vitamin D and Lifestyle for Gestational Diabetes Prevention Trial (DALI)

AU - Harreiter, Jürgen

AU - Mendoza, Lilian C.

AU - Simmons, David

AU - Desoye, Gernot

AU - Devlieger, Roland

AU - Galjaard, Sander

AU - Damm, Peter

AU - Mathiesen, Elisabeth R.

AU - Jensen, Dorte M.

AU - Andersen, Lise Lotte T.

AU - Dunne, Fidelma

AU - Lapolla, Annunziata

AU - Dalfra, Maria G.

AU - Bertolotto, Alessandra

AU - Wender-Ozegowska, Ewa

AU - Zawiejska, Agnieszka

AU - Hill, David

AU - Jelsma, Judith G.M.

AU - Snoek, Frank J.

AU - Worda, Christof

AU - Bancher-Todesca, Dagmar

AU - van Poppel, Mireille N.M.

AU - Corcoy, Rosa

AU - Kautzky-Willer, Alexandra

AU - on behalf of the DALI Core Investigator Group

N1 - Publisher Copyright: © 2022 by the authors.

PY - 2022

Y1 - 2022

N2 - Vitamin D deficiency is a common finding in overweight/obese pregnant women and is associated with increased risk for adverse pregnancy outcome. Both maternal vitamin D deficiency and maternal obesity contribute to metabolic derangements in pregnancy. We aimed to assess the effects of vitamin D3 supplementation in pregnancy versus placebo on maternal and fetal lipids. Main inclusion criteria were: women <20 weeks’ gestation, BMI ≥ 29 kg/m2. Eligible women (n = 154) were randomized to receive vitamin D3 (1600 IU/day) or placebo. Assessments were performed <20, 24–28 and 35–37 weeks and at birth. Linear regression models were used to assess effects of vitamin D on maternal and cord blood lipids. In the vitamin D group significantly higher total 25-OHD and 25-OHD3 levels were found in maternal and cord blood compared with placebo. Adjusted regression models did not reveal any differences in triglycerides, LDL-C, HDL-C, free fatty acids, ketone bodies or leptin between groups. Neonatal sum of skinfolds was comparable between the two groups, but correlated positively with cord blood 25-OH-D3 (r = 0.34, p = 0.012). Vitamin D supplementation in pregnancy increases maternal and cord blood vitamin D significantly resulting in high rates of vitamin D sufficiency. Maternal and cord blood lipid parameters were unaffected by Vitamin D3 supplementation.

AB - Vitamin D deficiency is a common finding in overweight/obese pregnant women and is associated with increased risk for adverse pregnancy outcome. Both maternal vitamin D deficiency and maternal obesity contribute to metabolic derangements in pregnancy. We aimed to assess the effects of vitamin D3 supplementation in pregnancy versus placebo on maternal and fetal lipids. Main inclusion criteria were: women <20 weeks’ gestation, BMI ≥ 29 kg/m2. Eligible women (n = 154) were randomized to receive vitamin D3 (1600 IU/day) or placebo. Assessments were performed <20, 24–28 and 35–37 weeks and at birth. Linear regression models were used to assess effects of vitamin D on maternal and cord blood lipids. In the vitamin D group significantly higher total 25-OHD and 25-OHD3 levels were found in maternal and cord blood compared with placebo. Adjusted regression models did not reveal any differences in triglycerides, LDL-C, HDL-C, free fatty acids, ketone bodies or leptin between groups. Neonatal sum of skinfolds was comparable between the two groups, but correlated positively with cord blood 25-OH-D3 (r = 0.34, p = 0.012). Vitamin D supplementation in pregnancy increases maternal and cord blood vitamin D significantly resulting in high rates of vitamin D sufficiency. Maternal and cord blood lipid parameters were unaffected by Vitamin D3 supplementation.

KW - birth outcomes

KW - body fat distribution

KW - cholesterol

KW - cord blood

KW - free fatty acids

KW - lipids

KW - obesity pregnancy

KW - overweight

KW - pregnancy outcomes

KW - skinfolds

KW - triglycerides

KW - vitamin D

U2 - 10.3390/nu14183781

DO - 10.3390/nu14183781

M3 - Journal article

C2 - 36145157

AN - SCOPUS:85138320516

VL - 14

JO - Nutrients

JF - Nutrients

SN - 2072-6643

IS - 18

M1 - 3781

ER -

ID: 321290300