Socio-economic status, functioning and cognition in young versus adult patients newly diagnosed with bipolar disorder and their unaffected relatives: results from a cross-sectional study

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Background
Bipolar disorders (BD) figures on top of the World Health Organization classification of disabling disorders. It is unclear if there are socioeconomic, functioning, and cognition differences in young patients newly diagnosed with BD and whether these are different for young and adult patients newly diagnosed with BD. Understanding these differences is important for tailored treatment and support.

Methods
Participant groups included 401 patients newly diagnosed with BD, 145 of their unaffected first-degree relatives (UR) and 209 healthy control individuals (HC). First, we compared socio-economic status, functioning and cognition between young patients newly diagnosed with BD (150), UR (61) and HC (92) (15–25 years) and adult patients newly diagnosed with BD (251), UR (84) and HC (117) (>25 years), respectively.

Second, within patients, we compared functioning and cognition between young and adult patients newly diagnosed with BD.

Results
In both participant groups, patients newly diagnosed with BD, and to a lesser degree UR, had lower socio-economic status and impaired functioning and cognition compared with HC. Further, young patients newly diagnosed with BD were less functionally impaired, than adults newly diagnosed with BD, whereas cognition did not differ between groups.

Limitations
Applied tools for assessments of functioning and cognition are not validated below age 18.

Conclusions
Overall, lower socio-economic status and impaired functioning and cognition were found both in young and adult patients newly diagnosed with BD and their UR compared with young and adult HC, respectively. Young patients were less functionally impaired than adults, but cognition was similarly impaired.
OriginalsprogEngelsk
TidsskriftJournal of Affective Disorders
Vol/bind351
Sider (fra-til)458-471
Antal sider14
ISSN0165-0327
DOI
StatusUdgivet - 2024

Bibliografisk note

Funding Information:
The study was supported by grants from the Mental Health Services, Capital Region of Denmark (PhD student 164019 and the BIO study), The Danish Council for Independent Research, Medical Sciences ( DFF- 4183-00570 ), the A.P. Møller Foundation for the Advancement of Medical Science ( 15-55 ), and Beckett-Fonden ( 48282 ).

Publisher Copyright:
© 2024 Elsevier B.V.

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