Recombinant HCV variants with NS5A from genotypes 1-7 have different sensitivities to an NS5A inhibitor but not interferon-a
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Heterogeneity in the hepatitis C virus (HCV) protein NS5A influences its sensitivity to interferon-based therapy. Furthermore, NS5A is an important target for development of HCV-specific inhibitors. We aimed to develop recombinant infectious cell culture systems that express NS5A from isolates of the 7 major HCV genotypes, and determining their sensitivity to a specific NS5A inhibitor and to interferon-a.
Originalsprog | Engelsk |
---|---|
Tidsskrift | Gastroenterology Today |
Vol/bind | 140 |
Udgave nummer | 3 |
Sider (fra-til) | 1032-42 |
Antal sider | 11 |
ISSN | 0969-0131 |
DOI | |
Status | Udgivet - 2011 |
ID: 40330172