Principles of adoptive T cell therapy in cancer
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Adoptive cell therapy (ACT) utilizing either tumor-infiltrating lymphocyte (TIL)-derived T cells or T cells genetically engineered to express tumor recognizing receptors has emerged as a powerful and potentially curative therapy for several cancers. Many ACT-based therapies have recently entered late-phase clinical testing, with several T cell therapies already achieving regulatory approval for the treatment of patients with B cell malignancies. In this review, we briefly outline the principles of adoptively transferred T cells for the treatment of cancer.
Originalsprog | Engelsk |
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Tidsskrift | Seminars in Immunopathology |
Vol/bind | 41 |
Udgave nummer | 1 |
Sider (fra-til) | 49–58 |
ISSN | 1863-2297 |
DOI | |
Status | Udgivet - 11 jan. 2019 |
ID: 208885873