Özcan Met

Özcan Met


Medlem af:

    Primære forskningsområder

    My current research focus is in the area of molecular and cellular tumor immunology, particularly the development of gene-engineered T cells, tailored to treat cancer:

    (1) engineering of T cells with tumor-specific synthetic TCRs or chimeric antigen receptors (CARs) for adoptive immunotherapy (ACT)

    (2) manipulate co-stimulatory pathways to improve expansion of tumor-resident tumor-infiltrating lymphocytes (TILs) enriched for tumor specificity

    (3) genome editing using CRISPR/Cas9 to target cell-intrinsic pathways that restrict T-cell effector functions and their anti-tumor potential

    (4) Development of isolation and expansion methods for TIL therapy and to produce large-scale GMP-grade TIL products for ACT clinical trials of melanoma and other solid tumors

    ID: 33971757