Nitric oxide contributes to cytokine-induced apoptosis in pancreatic beta cells via potentiation of JNK activity and inhibition of Akt
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Pro-inflammatory cytokines cause beta cell secretory dysfunction and apoptosis--a process implicated in the pathogenesis of type 1 diabetes. Cytokines induce the expression of inducible nitric oxide (NO) synthase (iNOS) leading to NO production. NO contributes to cytokine-induced apoptosis, but the underlying mechanisms are unclear. The aim of this study was to investigate whether NO modulates signalling via mitogen-activated protein kinases (MAPKs) and Akt.
Originalsprog | Engelsk |
---|---|
Tidsskrift | Diabetologia |
Vol/bind | 48 |
Udgave nummer | 10 |
Sider (fra-til) | 2039-50 |
Antal sider | 12 |
ISSN | 0012-186X |
DOI | |
Status | Udgivet - 1 okt. 2005 |
ID: 33902384