Nitric oxide contributes to cytokine-induced apoptosis in pancreatic beta cells via potentiation of JNK activity and inhibition of Akt

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Standard

Nitric oxide contributes to cytokine-induced apoptosis in pancreatic beta cells via potentiation of JNK activity and inhibition of Akt. / Størling, J; Binzer, J; Andersson, Annica; Züllig, R A; Tonnesen, M; Knudsen, René Lehmann Pulz; Spinas, G A; Sandler, S; Billestrup, N; Mandrup-Poulsen, Thomas.

I: Diabetologia, Bind 48, Nr. 10, 01.10.2005, s. 2039-50.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Størling, J, Binzer, J, Andersson, A, Züllig, RA, Tonnesen, M, Knudsen, RLP, Spinas, GA, Sandler, S, Billestrup, N & Mandrup-Poulsen, T 2005, 'Nitric oxide contributes to cytokine-induced apoptosis in pancreatic beta cells via potentiation of JNK activity and inhibition of Akt', Diabetologia, bind 48, nr. 10, s. 2039-50. https://doi.org/10.1007/s00125-005-1912-2

APA

Størling, J., Binzer, J., Andersson, A., Züllig, R. A., Tonnesen, M., Knudsen, R. L. P., Spinas, G. A., Sandler, S., Billestrup, N., & Mandrup-Poulsen, T. (2005). Nitric oxide contributes to cytokine-induced apoptosis in pancreatic beta cells via potentiation of JNK activity and inhibition of Akt. Diabetologia, 48(10), 2039-50. https://doi.org/10.1007/s00125-005-1912-2

Vancouver

Størling J, Binzer J, Andersson A, Züllig RA, Tonnesen M, Knudsen RLP o.a. Nitric oxide contributes to cytokine-induced apoptosis in pancreatic beta cells via potentiation of JNK activity and inhibition of Akt. Diabetologia. 2005 okt. 1;48(10):2039-50. https://doi.org/10.1007/s00125-005-1912-2

Author

Størling, J ; Binzer, J ; Andersson, Annica ; Züllig, R A ; Tonnesen, M ; Knudsen, René Lehmann Pulz ; Spinas, G A ; Sandler, S ; Billestrup, N ; Mandrup-Poulsen, Thomas. / Nitric oxide contributes to cytokine-induced apoptosis in pancreatic beta cells via potentiation of JNK activity and inhibition of Akt. I: Diabetologia. 2005 ; Bind 48, Nr. 10. s. 2039-50.

Bibtex

@article{38f343dd25b74ea88afe89b7d6126419,
title = "Nitric oxide contributes to cytokine-induced apoptosis in pancreatic beta cells via potentiation of JNK activity and inhibition of Akt",
abstract = "Pro-inflammatory cytokines cause beta cell secretory dysfunction and apoptosis--a process implicated in the pathogenesis of type 1 diabetes. Cytokines induce the expression of inducible nitric oxide (NO) synthase (iNOS) leading to NO production. NO contributes to cytokine-induced apoptosis, but the underlying mechanisms are unclear. The aim of this study was to investigate whether NO modulates signalling via mitogen-activated protein kinases (MAPKs) and Akt.",
keywords = "Animals, Apoptosis, Blotting, Western, Cell Separation, Cells, Cultured, Cytokines, Dose-Response Relationship, Drug, Enzyme Activation, Enzyme Inhibitors, Humans, Insulin, Insulin-Secreting Cells, MAP Kinase Kinase 4, Mice, Mitogen-Activated Protein Kinases, NG-Nitroarginine Methyl Ester, Nitric Oxide, Nitric Oxide Donors, Nitric Oxide Synthase Type II, Oncogene Protein v-akt, S-Nitroso-N-Acetylpenicillamine, Signal Transduction, p38 Mitogen-Activated Protein Kinases",
author = "J St{\o}rling and J Binzer and Annica Andersson and Z{\"u}llig, {R A} and M Tonnesen and Knudsen, {Ren{\'e} Lehmann Pulz} and Spinas, {G A} and S Sandler and N Billestrup and Thomas Mandrup-Poulsen",
year = "2005",
month = oct,
day = "1",
doi = "10.1007/s00125-005-1912-2",
language = "English",
volume = "48",
pages = "2039--50",
journal = "Diabetologia",
issn = "0012-186X",
publisher = "Springer",
number = "10",

}

RIS

TY - JOUR

T1 - Nitric oxide contributes to cytokine-induced apoptosis in pancreatic beta cells via potentiation of JNK activity and inhibition of Akt

AU - Størling, J

AU - Binzer, J

AU - Andersson, Annica

AU - Züllig, R A

AU - Tonnesen, M

AU - Knudsen, René Lehmann Pulz

AU - Spinas, G A

AU - Sandler, S

AU - Billestrup, N

AU - Mandrup-Poulsen, Thomas

PY - 2005/10/1

Y1 - 2005/10/1

N2 - Pro-inflammatory cytokines cause beta cell secretory dysfunction and apoptosis--a process implicated in the pathogenesis of type 1 diabetes. Cytokines induce the expression of inducible nitric oxide (NO) synthase (iNOS) leading to NO production. NO contributes to cytokine-induced apoptosis, but the underlying mechanisms are unclear. The aim of this study was to investigate whether NO modulates signalling via mitogen-activated protein kinases (MAPKs) and Akt.

AB - Pro-inflammatory cytokines cause beta cell secretory dysfunction and apoptosis--a process implicated in the pathogenesis of type 1 diabetes. Cytokines induce the expression of inducible nitric oxide (NO) synthase (iNOS) leading to NO production. NO contributes to cytokine-induced apoptosis, but the underlying mechanisms are unclear. The aim of this study was to investigate whether NO modulates signalling via mitogen-activated protein kinases (MAPKs) and Akt.

KW - Animals

KW - Apoptosis

KW - Blotting, Western

KW - Cell Separation

KW - Cells, Cultured

KW - Cytokines

KW - Dose-Response Relationship, Drug

KW - Enzyme Activation

KW - Enzyme Inhibitors

KW - Humans

KW - Insulin

KW - Insulin-Secreting Cells

KW - MAP Kinase Kinase 4

KW - Mice

KW - Mitogen-Activated Protein Kinases

KW - NG-Nitroarginine Methyl Ester

KW - Nitric Oxide

KW - Nitric Oxide Donors

KW - Nitric Oxide Synthase Type II

KW - Oncogene Protein v-akt

KW - S-Nitroso-N-Acetylpenicillamine

KW - Signal Transduction

KW - p38 Mitogen-Activated Protein Kinases

U2 - 10.1007/s00125-005-1912-2

DO - 10.1007/s00125-005-1912-2

M3 - Journal article

C2 - 16132952

VL - 48

SP - 2039

EP - 2050

JO - Diabetologia

JF - Diabetologia

SN - 0012-186X

IS - 10

ER -

ID: 33902384