Mechanisms of topoisomerase I (TOP1) gene copy number increase in a stage III colorectal cancer patient cohort

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Standard

Mechanisms of topoisomerase I (TOP1) gene copy number increase in a stage III colorectal cancer patient cohort. / Smith, David Hersi; Christensen, Ib Jarle; Jensen, Niels Frank; Markussen, Bo; Rømer, Maria Unni Koefoed; Nygård, Sune Boris; Müller, Sven; Nielsen, Hans Jørgen; Brünner, Nils; Nielsen, Kirsten Vang.

I: P L o S One, Bind 8, Nr. 4, e60613, 2013.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Smith, DH, Christensen, IJ, Jensen, NF, Markussen, B, Rømer, MUK, Nygård, SB, Müller, S, Nielsen, HJ, Brünner, N & Nielsen, KV 2013, 'Mechanisms of topoisomerase I (TOP1) gene copy number increase in a stage III colorectal cancer patient cohort', P L o S One, bind 8, nr. 4, e60613. https://doi.org/10.1371/journal.pone.0060613

APA

Smith, D. H., Christensen, I. J., Jensen, N. F., Markussen, B., Rømer, M. U. K., Nygård, S. B., ... Nielsen, K. V. (2013). Mechanisms of topoisomerase I (TOP1) gene copy number increase in a stage III colorectal cancer patient cohort. P L o S One, 8(4), [e60613]. https://doi.org/10.1371/journal.pone.0060613

Vancouver

Smith DH, Christensen IJ, Jensen NF, Markussen B, Rømer MUK, Nygård SB o.a. Mechanisms of topoisomerase I (TOP1) gene copy number increase in a stage III colorectal cancer patient cohort. P L o S One. 2013;8(4). e60613. https://doi.org/10.1371/journal.pone.0060613

Author

Smith, David Hersi ; Christensen, Ib Jarle ; Jensen, Niels Frank ; Markussen, Bo ; Rømer, Maria Unni Koefoed ; Nygård, Sune Boris ; Müller, Sven ; Nielsen, Hans Jørgen ; Brünner, Nils ; Nielsen, Kirsten Vang. / Mechanisms of topoisomerase I (TOP1) gene copy number increase in a stage III colorectal cancer patient cohort. I: P L o S One. 2013 ; Bind 8, Nr. 4.

Bibtex

@article{5e0a11a7e4ae47adb469fecc37fdacd9,
title = "Mechanisms of topoisomerase I (TOP1) gene copy number increase in a stage III colorectal cancer patient cohort",
abstract = "Topoisomerase I (Top1) is the target of Top1 inhibitor chemotherapy. The TOP1 gene, located at 20q12-q13.1, is frequently detected at elevated copy numbers in colorectal cancer (CRC). The present study explores the mechanism, frequency and prognostic impact of TOP1 gene aberrations in stage III CRC and how these can be detected by fluorescent in situ hybridization (FISH).",
author = "Smith, {David Hersi} and Christensen, {Ib Jarle} and Jensen, {Niels Frank} and Bo Markussen and R{\o}mer, {Maria Unni Koefoed} and Nyg{\aa}rd, {Sune Boris} and Sven M{\"u}ller and Nielsen, {Hans J{\o}rgen} and Nils Br{\"u}nner and Nielsen, {Kirsten Vang}",
year = "2013",
doi = "10.1371/journal.pone.0060613",
language = "English",
volume = "8",
journal = "P L o S One",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "4",

}

RIS

TY - JOUR

T1 - Mechanisms of topoisomerase I (TOP1) gene copy number increase in a stage III colorectal cancer patient cohort

AU - Smith, David Hersi

AU - Christensen, Ib Jarle

AU - Jensen, Niels Frank

AU - Markussen, Bo

AU - Rømer, Maria Unni Koefoed

AU - Nygård, Sune Boris

AU - Müller, Sven

AU - Nielsen, Hans Jørgen

AU - Brünner, Nils

AU - Nielsen, Kirsten Vang

PY - 2013

Y1 - 2013

N2 - Topoisomerase I (Top1) is the target of Top1 inhibitor chemotherapy. The TOP1 gene, located at 20q12-q13.1, is frequently detected at elevated copy numbers in colorectal cancer (CRC). The present study explores the mechanism, frequency and prognostic impact of TOP1 gene aberrations in stage III CRC and how these can be detected by fluorescent in situ hybridization (FISH).

AB - Topoisomerase I (Top1) is the target of Top1 inhibitor chemotherapy. The TOP1 gene, located at 20q12-q13.1, is frequently detected at elevated copy numbers in colorectal cancer (CRC). The present study explores the mechanism, frequency and prognostic impact of TOP1 gene aberrations in stage III CRC and how these can be detected by fluorescent in situ hybridization (FISH).

U2 - 10.1371/journal.pone.0060613

DO - 10.1371/journal.pone.0060613

M3 - Journal article

C2 - 23577133

VL - 8

JO - P L o S One

JF - P L o S One

SN - 1932-6203

IS - 4

M1 - e60613

ER -

ID: 45196253