Mechanisms of topoisomerase I (TOP1) gene copy number increase in a stage III colorectal cancer patient cohort

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Topoisomerase I (Top1) is the target of Top1 inhibitor chemotherapy. The TOP1 gene, located at 20q12-q13.1, is frequently detected at elevated copy numbers in colorectal cancer (CRC). The present study explores the mechanism, frequency and prognostic impact of TOP1 gene aberrations in stage III CRC and how these can be detected by fluorescent in situ hybridization (FISH).
OriginalsprogEngelsk
Artikelnummere60613
TidsskriftP L o S One
Vol/bind8
Udgave nummer4
Antal sider10
ISSN1932-6203
DOI
StatusUdgivet - 2013

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