Impact of high-intensity interval training on cardiac structure and function after COVID-19: an investigator-blinded randomized controlled trial

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

  • Cody Garett Durrer
  • Frederik Foged
  • Vera Graungaard Schelde
  • Josephine Bjørn Budde
  • Rasmus Syberg Rasmussen
  • Emma Fredskild Høvighoff
  • Villads Rasmussen
  • Mark Lyngbæk
  • Simon Jønck
  • Peter Godsk Jørgensen
  • Niels Vejlstrup
  • Mathias Ried-Larsen
  • Regitse Højgaard Christensen
A large proportion of patients suffer from a persistent reduction in cardiorespiratory fitness after recovery from COVID-19, of which the effects on the heart may potentially be reversed through the effect of high-intensity interval training (HIIT). In the present study, we hypothesized that HIIT would increase left ventricular mass (LVM) and improve functional status and health-related quality of life (HRQoL) in individuals previously hospitalized for COVID-19. In this investigator-blinded, randomized controlled trial, 12 weeks of supervised HIIT (4x4 minutes, three times a week) was compared to standard care (control) in individuals recently discharged from hospital due to COVID-19. LVM was assessed by cardiac magnetic resonance imaging (cMRI, primary outcome), while the pulmonary diffusing capacity (DLCOc, secondary outcome) was examined by the single-breath method. Functional status and HRQoL was assessed by Post-COVID-19 Functional Scale (PCFS) and King's brief interstitial lung disease (KBILD) questionnaire, respectively. A total of 28 participants were included (age 57±10, 9 females; HIIT: 58±11, 4 females; standard care: 57±9, 5 females), LVM increased in the HIIT vs. standard care group with a between-group difference of 6.8 [mean, 95%CI: 0.8; 12.8] g; p=0.029. There were no between-group differences in DLCOc or any other lung function metric, which gradually resolved in both groups. Desriptively, PCFS suggested fewer functional limitations in the HIIT group. KBILD improved similarly in the two groups. HIIT is an efficacious exercise intervention for increasing LVM in individuals previously hospitalized for COVID-19.
TidsskriftJournal of applied physiology (Bethesda, Md. : 1985)
Udgave nummer2
Sider (fra-til)s239-488
StatusUdgivet - 2023

ID: 360609375