Highly effective SNP-based association mapping and management of recessive defects in livestock

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

  • Carole Charlier
  • Wouter Coppieters
  • Frédéric Rollin
  • Daniel Desmecht
  • Nadine Cambisano
  • Eloisa Carta
  • Sabrina Dardano
  • Marc Dive
  • Corinne Fasquelle
  • Jean-Claude Frennet
  • Roger Hanset
  • Xavier Hubin
  • Latifa Karim
  • Matthew Kent
  • Kirsten Harvey
  • Brian R. Pearce
  • Patricia Simon
  • Nico Tama
  • Haisheng Nie
  • Sébastien Vandeputte
  • Sigbjorn Lien
  • Maria Longeri
  • Robert J. Harvey
  • Michel Georges
The widespread use of elite sires by means of artificial insemination in livestock breeding leads to the frequent emergence of recessive genetic defects, which cause significant economic and animal welfare concerns. Here we show that the availability of genome-wide, high-density SNP panels, combined with the typical structure of livestock populations, markedly accelerates the positional identification of genes and mutations that cause inherited defects. We report the fine-scale mapping of five recessive disorders in cattle and the molecular basis for three of thee: congenital muscular dystony (CMD) types 1 and 2 in Belgian Blue cattle and ichthyosis fetalis in Italian Chianina cattle. Identification of these causative mutations has an immediate translation into breeding practive, allowing marker assisted selection against the defects through avoidance of at-risk matings.
TidsskriftNature Genetics
Udgave nummer4
Sider (fra-til)449-454
Antal sider6
StatusUdgivet - 2008

ID: 8104877