Expression of the domain cassette 8 Plasmodium falciparum erythrocyte membrane protein 1 is associated with cerebral malaria in Benin
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Plasmodium falciparum erythrocyte membrane protein-1 (PfEMP-1) is a highly polymorphic adherence receptor expressed on the surface of infected erythrocytes. Based on sequence homology PfEMP-1 variants have been grouped into three major groups A-C, the highly conserved VAR2CSA variants, and semi-conserved types defined by tandem runs of specific domains ("domain cassettes" (DC)). The PfEMP-1 type expressed determines the adherence phenotype, and is associated with clinical outcome of infection.
Originalsprog | Engelsk |
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Tidsskrift | P L o S One |
Vol/bind | 8 |
Udgave nummer | 7 |
Sider (fra-til) | e68368 |
ISSN | 1932-6203 |
DOI | |
Status | Udgivet - 2013 |
ID: 80644452