Exploring the relationship between the conformation and pKa: can a pKa value be used to determine the conformational equilibrium?
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Four substituted cis and trans-4,5-dihydroxyhexahydropyridazines that were expected to undergo pH induced conformational switching were synthesized and carefully investigated by NMR analyses and calculations. For two of the compounds a large difference in pKa existed between the two possible chair conformers and for one compound this resulted in conformational switching as a result of pH change. For the first time it is shown that the pKa directly reflects the conformational equilibrium of conformers.
Originalsprog | Engelsk |
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Tidsskrift | Organic & Biomolecular Chemistry |
Vol/bind | 13 |
Udgave nummer | 10 |
Sider (fra-til) | 3116-3121 |
Antal sider | 6 |
ISSN | 1477-0520 |
DOI | |
Status | Udgivet - 2015 |
ID: 130175087