Efficacy of natural antimicrobial peptides versus peptidomimetic analogues: a systematic review
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
Dokumenter
- Fulltext
Forlagets udgivne version, 1,73 MB, PDF-dokument
Aims: This systematic review was carried out to determine whether synthetic peptidomimetics exhibit significant advantages over antimicrobial peptides (AMPs) in terms of in vitro potency. Structural features - molecular weight, charge and length - were examined for correlations with activity. Methods: Original research articles reporting minimum inhibitory concentration (MIC) values against Escherichia coli, indexed until 31 December 2020, were searched in PubMed/ScienceDirect/Google Scholar and evaluated using mixed-effects models. Results: In vitro antimicrobial activity of peptidomimetics resembled that of AMPs. Net charge significantly affected MIC values (p < 0.001) with a trend of 4.6% decrease for increments in charge by +1. Conclusion: AMPs and antibacterial peptidomimetics exhibit similar potencies, providing an opportunity to exploit the advantageous stability and bioavailability typically associated with peptidomimetics.
Originalsprog | Engelsk |
---|---|
Tidsskrift | Future Medicinal Chemistry |
Vol/bind | 14 |
Udgave nummer | 24 |
Sider (fra-til) | 1899–1921 |
ISSN | 1756-8919 |
DOI | |
Status | Udgivet - 2022 |
Antal downloads er baseret på statistik fra Google Scholar og www.ku.dk
ID: 327059670